Drug glucuronidation in humans
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2021, Pharmacology and TherapeuticsCitation Excerpt :Given the scope of the glucuronidation reaction, it is not surprising that conjugation with glucuronic acid plays an important role in the metabolism of a myriad of compounds. In particular, glucuronidation is an elimination pathway for drugs from almost all therapeutic classes (Kiang, Ensom, & Chang, 2005; Miners & Mackenzie, 1991; Miners, Mackenzie, & Knights, 2010; Stingl, Bartels, Viviani, Lehmann, & Brockmoller, 2014). Evans and Relling (1999) estimated that glucuronidation was the primary route of metabolism for approximately 40% of drugs eliminated by conjugation enzymes, while an analysis of the 200 top-prescribed drugs in 2002 demonstrated that glucuronidation was the second most common metabolic pathway after cytochrome P450 (CYP) catalysed oxidation (Evans & Relling, 1999; Williams et al., 2004).
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