Intestinal absorption and metabolism of hydrocarbons
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Cited by (37)
Mineral oil risk assessment: Knowledge gaps and roadmap. Outcome of a multi-stakeholders workshop
2021, Trends in Food Science and TechnologyCitation Excerpt :These results suggest that the immunotoxic effect of MOSH is route-specific and not relevant for long-term dietary intake of MOSH. Based on the limited data available, MOAH appears to be absorbed following ingestion (Barrowman, Rahman, Lindstrom, & Borgstrom, 1989; Bevan et al., 2020). After absorption, MOAHs are oxidatively metabolised by CYP which partly explains why they do not accumulate in the body.
Association of metabolites with obesity based on two gene variants, MC4R rs17782313 and BDNF rs6265
2021, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :It was suggested that colonic microbiome is responsible for increase in VOC of obese nonalcoholic fatty liver disease patients. As long chain hydrocarbons are highly hydrophobic; they generally bioaccumulate in adipose tissues [40]. Therefore, we observed lower levels of tetradecane in cases as compared to controls and found highly associated with obesity (B-coefficient = 1.539).
Evaluating the risk to humans from mineral oils in foods: Current state of the evidence
2020, Food and Chemical ToxicologySuitability of n-alkanes and chromium (III) oxide as digestibility markers in calves at the end of the milk feeding period supplemented with a prebiotic
2018, Animal NutritionCitation Excerpt :There are several possibilities for the lower recovery of alkanes observed in this current study. Alkanes could either have been absorbed in the gastrointestinal tract, metabolized by the enterocytes or microflora or chemically interacted with other substances in the digesta (e.g., nutrients or enzymes) and thus form new chemical compounds (Barrowman et al., 1989). There have been no investigations yet where and how alkanes may disappear during their gastrointestinal passage.
Mineral oil saturated hydrocarbons (MOSH) in female Fischer 344 rats; accumulation of wax components; implications for risk assessment
2017, Science of the Total EnvironmentCitation Excerpt :The two routes of intestinal absorption, namely the lymph and the portal venous routes, might play a role. The lymph route was reported as the major one for C16–C19 alkanes (Barrowman et al. (1989), but no data on absorption of long chain alkanes were identified. In liver and spleen, the selectivity determining the MOSH composition could be explained by elimination: the residues are composed of hydrocarbons resisting elimination, either by structural hindrance against metabolism or precipitation.
Green tea extract markedly lowers the lymphatic absorption and increases the biliary secretion of <sup>14</sup>C-benzo[a]pyrene in rats
2012, Journal of Nutritional BiochemistryCitation Excerpt :At present, however, no evidence exists that GTE or its catechins regulate the efflux of BaP metabolites into the intestinal lumen involving ABC transporters including BCRP and other transporters such as P-glycoproteins and multidrug-resistant proteins. The soluble metabolites of BaP produced in the enterocyte can also be transported directly to the liver via the portal vein [7,8]. Although the lymphatic pathway via chylomicrons represents a major route for BaP absorption, an earlier study [37] using a ligated rat jejunal loop showed that a significant proportion (∼40%) of the BaP dose was recovered in the portal blood largely as soluble metabolites.