Trends in Pharmacological Sciences
TIPS reviewCytochrome P-450 catalysis: radical intermediates and dehydrogenation reactions
References (27)
- et al.
J. Biol. Chem.
(1989) - et al.
J. Biol. Chem.
(1987) - et al.
Biochem. Pharmacol.
(1988) - et al.
Life Sci.
(1979) - et al.
Chem.-Biol. Interact.
(1988) - et al.
Biochem. Biophys. Res. Commun.
(1982) J. Biol. Chem.
(1988)- et al.
Pestic. Biochem. Physiol.
(1975) - et al.
Biochem. Biophys. Res. Commun.
(1983) - et al.
J. Biol. Chem.
(1988)
Arch. Biochem. Biophys.
J. Am. Chem. Soc.
Cited by (98)
Novel oxazolinyl derivatives of pregna-5,17(20)-diene as 17α-hydroxylase/17,20-lyase (CYP17A1) inhibitors
2014, SteroidsCitation Excerpt :Binding of oxazolinyl derivatives of [17(20)E]-pregna-5,17(20)-diene 1 and 2 to human recombinant CYP17A1 [24] was evaluated by absorption spectroscopy, as reported earlier for the characterization of interaction of steroidal CYP17A1 inhibitors abiraterone and TOK-001 with truncated, His-tagged version of the human CYP17A1 protein [21]. The spectrum of CYP17A1 (Fig. 2, insert) showed the maximum at 417 nm; titration of enzyme with substrate pregnenolone revealed absorbance decrease at 417 nm and increase at 386 nm, indicative of ligand displacing water from the heme (type I interaction [29,30]); titration of enzyme with abiraterone 3 caused appearance of characteristic maximum at 424 nm and minimum at 390 nm, corresponding to formation of coordinate bond between abiraterone pyridine nitrogen and heme iron (type II interaction [29,30]). Differential absorption spectra of CYP17A1 in the presence of pregnenolone, compounds 1, 2, and 3 recorded at saturating concentrations of ligands are shown in Fig. 2.
Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: Synthesis, biological evaluation and nitric oxide release studies
2010, Bioorganic and Medicinal Chemistry LettersCatalytic diversity of fatty acid desaturases
2004, Tetrahedron AsymmetryCitation Excerpt :The consensus mechanistic model for desaturase-mediated dehydrogenation (Scheme 2) is based on an early proposal of Ortiz de Montellano for the corresponding cytochrome P450 enzymes.20
Two-state reactivity mechanisms of hydroxylation and epoxidation by cytochrome P-450 revealed by theory
2002, Current Opinion in Chemical BiologyMercury and methylmercury differentially modulate hepatic cytochrome P450 1A1 and 1A2 in vivo and in vitro
2023, Journal of Biochemical and Molecular ToxicologyAllergic Contact Dermatitis: Chemical and Metabolic Mechanisms
2023, Allergic Contact Dermatitis: Chemical and Metabolic Mechanisms