The effect of age and gender on glucuronidation and sulphation in rat liver: a study using paracetamol as a model substrate

https://doi.org/10.1016/0167-4943(93)90002-YGet rights and content

Abstract

The effect of age and sex on glucuronidation and sulphation was studied in vitro in rat liver fractions, using paracetamol (acetaminophen) as substrate. Glucuronidation was more rapid in females; sulphation in males. Age was not a determinant of either metabolic pathway in either sex.

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