Severe cholestasis and sicca syndrome after thiabendazole
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The fungicide thiabendazole causes apoptosis in rat hepatocytes
2016, Toxicology in VitroCitation Excerpt :Thiabendazole is generally considered to be of low acute toxicity (USEPA, 2002). However, cases of severe intrahepatic cholestasis often progressing to micronodular cirrhosis have been reported (Manivel et al., 1987; Roy et al., 1989; Bion et al., 1995; Mohi-ud-din and Lewis, 2004). Parenchymal liver damage caused by thiabendazole has occasionally led to irreversible hepatic failure (FDA, 2003; EMA, 2004).
Determination of 5-hydroxythiabendazole in human urine as a biomarker of exposure to thiabendazole using LC/MS/MS
2014, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesCitation Excerpt :However, humans treated with TBZ as an anthelmintic, have experienced adverse effects, like abdominal pain and nausea, dizziness and other cognitive complaints [3–5]. Serious effects such as liver diseases have also been reported [6] and in animal studies adverse kidney and liver effects, as well as teratogenic and reproductive toxicity at high doses [7–10]. TBZ is very toxic to aquatic organisms, and release of TBZ-containing waste water into the environment is prohibited within the EU [2].
Chronic toxicity of thiabendazole (TBZ) in CD-1 mice
2001, ToxicologyThiabendazole induces urinary tract toxicity in male ICR mice
2001, ToxicologyHistological patterns in drug-induced liver disease
2009, Journal of Clinical Pathology