Research sectionInduction of rat hepatic cytochrome P-450 I proteins by the antimutagen anthraflavic acid
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Cited by (15)
Modulation of heterocyclic amine-induced mutagenicity and carcinogenicity: An 'A-to-Z' guide to chemopreventive agents, promoters, and transgenic models
2002, Mutation Research - Reviews in Mutation ResearchHeterogenous effects of anthraquinones on drug-metabolizing enzymes in the liver and small intestine of rat
2000, Chemico-Biological InteractionsCitation Excerpt :So far no information is available on the potential of AQs to induce P450 1A or other drug-metabolizing enzymes in the intestine and little is known on the modulation of these enzymes in the liver. Ioannides et al. [16,17] reported that the 2,6-dihydroxyanthraquinone was able to enhance the hepatic EROD activity and the apoprotein levels of both 1A1 and 1A2 in rat but it was not ascertained if the transcriptional of P450 1A1 or 1A2 mRNA or both were induced. The induction by AQs of P450 1A2 but not P450 1A1 is possible since in mice the administration of various tricyclic PAHs induces only 1A2 [18].
Consumption of tea modulates the urinary excretion of mutagens in rats treated with IQ. Role of caffeine
1999, Mutation Research - Genetic Toxicology and Environmental MutagenesisEvaluation of the antimutagenic potential of anthracene: in vitro and ex vivo studies
1994, Mutation Research Regular PapersProtection against Trp-P-2 DNA adduct formation in C57bl6 mice by purpurin is accompanied by induction of cytochrome P450
2003, Journal of Agricultural and Food Chemistry
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