In vitro and in vivo reversible and irreversible inhibition of rat glutathione S-transferase isoenzymes by caffeic acid and its 2-S-glutathionyl conjugate
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Organotin(IV) complexes with epigenetic modulator ligands: New promising candidates in cancer therapy
2022, Inorganica Chimica ActaCitation Excerpt :As a primary antioxidant it acts by interrupting the formation of free radicals by inhibiting chain reactions with another molecule; in contrast, as a secondary antioxidant, it acts as a chelating agent [86,87]. Besides its well-known antioxidant activity [86,87] H3CAF inhibits certain enzyme activities such as lipoxygenases, cyclooxygenase, glutathione S-transferase, and xanthine oxidase [88–92]. H3CAF has been reported also to have antitumor activity [93,94].
Acute toxicity study in mice of orally administrated TiO<inf>2</inf> nanoparticles functionalized with caffeic acid
2018, Food and Chemical ToxicologyThe role of the catecholic and the electrophilic moieties of caffeic acid in Nrf2/Keap1 pathway activation in ovarian carcinoma cell lines
2015, Redox BiologyCitation Excerpt :Indeed, we found that CA inhibits GST and GSR activity in vitro. This finding is in agreement with a previous work of Ploemen et al. [53]. GSR1 activity in A2780 cells (in these cells no increase in protein was observed) was inhibited by 50% but not in the resistant cells in which the protein levels were increased.
Adipokinetic hormone-induced antioxidant response in Spodoptera littoralis
2012, Comparative Biochemistry and Physiology - C Toxicology and PharmacologyCitation Excerpt :GSTs are a diverse family of detoxifying enzymes with a wide range of substrate specificity including products of oxidative metabolism like organic hydroperoxides, quinones and carbonyls (Mannervik and Danielson, 1988; Sawicki et al., 2003). There are evidences that GSTs are markedly inhibited by caffeic acid, which is chemically very similar to gallic acid (basic chemical unit of TA), and this inhibition is more potent after conjugation of caffeic acid with GSH (Ploemen et al., 1993). Moreover, many of the dietary phenolics (including gallic acid) and quinones can be oxidized within the insect gut or can be metabolized by peroxidases to form phenoxyl radicals which are sufficiently reactive to co-oxidize GSH and NADPH accompanied by ROS formation (Barbehenn and Martin, 1994; Galati et al., 1999, 2002; Salminen and Lempa, 2002).
The metabolic bioactivation of caffeic acid phenethyl ester (CAPE) mediated by tyrosinase selectively inhibits glutathione S-transferase
2011, Chemico-Biological InteractionsCitation Excerpt :The irreversible inhibition by CAPE of GST was shown in cell lysates, but not in intact cells, which contain GSH in mM levels [63]. Similar results were found with caffeic acid, albeit with less potent dose–response, and in agreement with results with caffeic acid reported by Ploemen et al. [41]. GST and MRP play vital roles in the protection of cancer cells against cancer therapy.
Hepatic and extrahepatic expression of glutathione S-transferase isozymes in mice and its modulation by naturally occurring phenolic acids
2008, Environmental Toxicology and PharmacologyCitation Excerpt :Consistently with our previous data on GST activity (Krajka-Kuźniak and Baer-Dubowska, 2003), tannic acid administered in a single i.p. dose of 80 mg/kg reduced the hepatic GST mu and alpha subunits in liver. The inhibition of GST activity, which coincided with a decrease of the mu class subunit was observed in early studies by Ploemen et al. (1993) in rat liver as a result of administration of single oral doses (50–500 mg/kg b.wt.) of caffeic acid, another naturally occurring phenolic acid.