Induction of cytochrome P-450-dependent enzyme activities in cultured rat liver slices
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Antagonistic and synergistic interactions during the binding of binary mixtures of polycyclic aromatic hydrocarbons to the aryl hydrocarbon receptor
2018, Toxicology in VitroCitation Excerpt :Slices from five animals were pooled together. The culture medium (RPMI 1640) was essentially that described by Lake et al. (1993) and contained the following: foetal calf serum (FCS) (5%), l-methionine (0.5 mM), insulin (1 μM), hydrocortisone-21-hemisuccinate (0.1 mM) and gentamycin (50 μg ml−1); one slice was placed in culture medium (1.5 ml) in each well. Incubation was performed for 24 h under sterile conditions, at a temperature of 37 °C and under an atmosphere of 95% O2/5% CO2, on a reciprocating plate shaker housed in a humidified incubator.
Up-regulation of CYP1A1 and phase II enzymes by 5-ring isomeric polycyclic aromatic hydrocarbons in precision-cut rat hepatic slices: Importance of molecular shape
2017, Toxicology in VitroCitation Excerpt :Slices were cultured using the multiwell plate system utilising 12-well culture plates. The culture medium (RPMI 1640) utilised was essentially that described by Lake et al. (1993) and contained foetal calf serum (FCS) (5%), l-methionine (0.5 mM), insulin (1 μM), hydrocortisone-21-hemisuccinate (0.1 mM) and gentamycin (50 μg ml− 1). One slice was placed in culture medium (1.5 ml) in each well, and incubation was carried out for 24 h under sterile conditions, at a temperature of 37 °C and under an atmosphere of 95% air/5% CO2, on a reciprocating plate shaker housed in a humidified incubator.
Constitutive Androstane Receptor
2010, Comprehensive Toxicology: Second EditionModulation of rat pulmonary carcinogen-metabolising enzyme systems by the isothiocyanates erucin and sulforaphane
2009, Chemico-Biological InteractionsCitation Excerpt :The multiwell plate procedure, using 12-well culture plates, was used to culture the slices. The culture medium was essentially that described by Lake et al. [19], and one slice was placed in each well, in 1.5 ml of culture medium. Slices were initially pre-incubated for 60 min in order to slough off any dead cells due to slicing, before being transferred to fresh medium and incubated for a period of 24 h in the presence of a range of concentrations of sulforaphane or erucin on a reciprocating plate shaker housed in a humidified incubator, at a temperature of 37 °C and under an atmosphere of 95% air/5% CO2.
Differential response of human and rat epoxide hydrolase to polycyclic aromatic hydrocarbon exposure: Studies using precision-cut tissue slices
2008, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis