Effect of microsomal enzyme activity modulation on N-(3,5-dichlorophenyl)succinimide-induced nephrotoxicity☆,☆☆
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Cited by (50)
Renal damage, metabolism and covalent binding following administration of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide (NDPS) to male Fischer 344 rats
2002, ToxicologyCitation Excerpt :In contrast, PB induction increased levels of 2-NDHSA, particularly in renal homogenates (Figs. 2 and 3). Modulation of enzyme activity was previously shown to alter NDPS nephrotoxicity in vivo (Rankin et al., 1987; Nyarko et al., 1997) and NDPS metabolism in vitro (Griffin et al., 1996; Nyarko and Harvison, 1995; Nyarko et al., 1997). Our results with the kidney homogenates establish an in vivo link between oxidative biotransformation of NDPS and greater exposure of kidney cells to 2-NDHSA, a known, potent in vivo nephrotoxicant (Rankin et al., 1988).
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Presented in part at the Sixty-ninth Annual Meeting of the Federation of American Societies for Experimental Biology, Anaheim, California, April 22–26, 1985.
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Supported by NIH Grant DK 31210.
Copyright © 1987 Published by Elsevier Ireland Ltd.