Subchronic 90 day toxicity of dichloroacetic and trichloroacetic acid in rats☆
References (35)
- et al.
Species differences in response to trichloroethylene. I. Pharmocokinetics in rats and mice
Toxicol. Appl. Pharmacol.
(1985) - et al.
Species differences in response to trichloroethylene. II. Biotransformation in rats and mice
Toxicol. Appl. Pharmacol.
(1985) - et al.
Effect of dichloroacetate on carbohydrate and lipid metabolism of isolated hepatocytes
Arch. Biochem. Biophys.
(1976) - et al.
The metabolic effects of dichloroacetate
Metabolism
(1981) - et al.
Dichloroacetate sodium: 3-month oral toxicity studies in rats and dogs
Toxicol. Appl. Pharmacol.
(1981) - et al.
The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver
Toxicol. Appl. Pharmacol.
(1987) - et al.
Biochemical, histological and ultrastructural changes in rat and mouse liver following administration of trichloroethylene: Possible relevance to species differences in hepatocarcinogenicity
Toxicol. Appl. Pharmacol.
(1985) - et al.
Immunotoxicity testing: An economical multiple-assay approach
Fund. Appl. Toxicol.
(1986) Assay of peroxisomal B-oxidation of fatty acids
Methods Enzymol.
(1981)- et al.
The carbon monoxide-binding pigment of liver microsomes
J. Biol. Chem.
(1964)
Direct fluorometric methods for measuring mixed-function oxidase activity
Methods Enzymol.
Assay of formaldehyde generated during microsomal oxidation reactions
Methods Enzymol.
Induction of strand breaks in DNA by TCE and metabolites in rat and mouse liver in vivo
Toxicol. Appl. Pharmacol.
EPA policies to protect the health of consumers of drinking water in the United States
Environ. Sci. Technol.
Gas chromatography/mass spectroscopy analysis of mutagenic extracts of aqueous chlorinated humic acid. A comparison of the byproducts of drinking water contaminants
Environ. Sci. Technol.
Determination of the aqueous chlorination products of humic substances by gas chromatography with microwave emission detection
Anal. Chem.
Characterization of nonvolatile aqueous chlorination products of humic substances
Environ. Sci. Technol.
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2015, ChemosphereCitation Excerpt :The International Agency for Research on Cancer has categorized TCAA as Group 3 (not classifiable as to its carcinogenicity in humans) despite animal tests showing that TCAA and DCAA are hepatotoxic and DCAA and DBAA adversely affecting male reproductive function (Linder et al., 1994). Both TCAA and DCAA caused substantial systematic organ toxicity, including liver and kidney damage, in rats in a 13-week subchronic study (Mather et al., 1990). In epidemiological studies, HAA exposure was significantly correlated with an increased risk of bladder (Villanueva et al., 2004) and colorectal cancers (Rahman et al., 2010).
Hepatoprotective activity of date fruit extracts against dichloroacetic acid-induced liver damage in rats
2014, Journal of Functional FoodsCitation Excerpt :The data in the present study showed that subchronic exposure to DCA at a dose of 0.5 or 2 g/l (33.78 or 131.24 mg/kg) changed body and relative liver weights, conducting to significant decreases in animal growth and production performances. These findings are similar to the results published by Mather et al. (1990). The increase in liver weight might be due mainly to the hypertrophy of liver which could arise from the accumulation of glycogen in hepatocytes (Carter, Carter, & DeAngelo, 1995).
Nephroprotective effect of date fruit extract against dichloroacetic acid exposure in adult rats
2014, Food and Chemical ToxicologyCitation Excerpt :The kidneys’ histological examination of DCA treated rats revealed many alterations pronounced mainly in rats treated with the higher concentration of DCA (2 g/L), demonstrating its harmful toxicity. Similar histopathological changes, characterized mainly by diffuse degeneration of the tubular epithelium and glomeruli, were observed by Mather et al. (1990). These damages were minimized in the groups treated with ADE suggesting the protective effects of this extract in attenuating DCA-induced histopathological changes.
Determination hematotoxic and hepatotoxic effects of trichloroacetic acid at sublethal dosage in rats
2009, Food and Chemical Toxicology
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