Drug and xenobiotic glucuronidation catalysed by cloned human liver UDP-Glucuronosyltransferases stably expressed in tissue culture cell lines
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UDP-glucuronosyltransferases (UGTs) and their related metabolic cross-talk with internal homeostasis: A systematic review of UGT isoforms for precision medicine
2017, Pharmacological ResearchCitation Excerpt :For instance, of 12 screened recombinant UGTs, edaravone glucuronide was formed through UGT 1A1, 1A6, 1A7, 1A9, 2B7 and 2B17. Paracetamol glucuronidation was catalyzed by UGT 1A1, 1A6, 1A9 and 2B15 [47–49]. However, on the other hand, each UGT isoform possesses its uniqueness no matter on the gene (unique exons or different regulatory elements, etc.) or protein (divergent amino terminal or distinct spatial configuration, etc.) structure.
Tandem mass spectrometric characterization of bile acids and steroid conjugates based on low-energy collision-induced dissociation
2014, SteroidsCitation Excerpt :Sulfation is the most commonly observed modification made during the body’s elimination of bile acids; sulfated bile acids constitute approximately 40% of total urinary bile acids [15]. Glucuronidation is known as an important detoxification route for low molecular weight compounds including drugs [16–19]. Since Back et al. [7,20] found bile acid glucuronides in the urine of cholestasis patients, the glucuronidation of bile acids had been thought to occur almost exclusively as an ether modifying a hydroxyl group at the C-3 position.
In vitro methods in human drug biotransformation research: Implications for cancer chemotherapy
2006, Toxicology in VitroAn update on in vitro test methods in human hepatic drug biotransformation research: Pros and cons
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