Use of tissue slices in chemical mixture toxicology and interspecies investigations

doi:10.1016/0300-483X(95)03224-4

Toxicology

Volume 105, Issues 2–3, 28 December 1995, Pages 285-290

https://doi.org/10.1016/0300-483X(95)03224-4 Get rights and content

Abstract

Precision-cut tissue slices have proven to be a useful in vitro system for biotransformation and toxicity studies. Since tissue slices can be readily prepared from a variety of tissues and species, they can easily be used for interspecies investigations and comparisons. Furthermore, slices can be readily prepared from human tissue, thus comparisons (extrapolation) can be made between laboratory animals and humans. Slices can also be used to examine the toxic interactions of chemicals in vitro. It is important to use the correct experimental design to demonstrate toxic interactions and to assure that the tissue slices are properly exposed to the chemicals. Overall, tissue slices offer a valid in vitro system for performing species comparisons and chemical-chemical interaction studies.

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Use of tissue slices in chemical mixture toxicology and interspecies investigations

Abstract

Fundam. Appl. Toxicol.

Toxicology

Toxicol. In Vitro

Chem.-Biol. Interact.

Toxicol. In Vitro

Life Sci.

Toxicol. In Vitro

Pharmacol. Methods

Toxicol. Appl. Pharmacol.

Fundam. Appl. Toxicol.

Precision-cut liver slices. An in vitro system for profiling potential hepatotoxicants

In Vitro Toxicol.

Toxicity of chlorobenzenes in cultured rat liver slices

In Vitro Toxicol.