Kids are different: developmental variability in toxicology
References (20)
- et al.
Studies of infants postnatally exposed to methylmercury
J. Pediatr.
(1974) - et al.
Mechanisms of lead toxicity
Biochem. Pharmacol.
(1991) Human fetal lead exposure: intrauterine growth, maturation, and postnatal neurobehavioral development
Fundam. Appl. Toxicol.
(1991)- et al.
Low-level lifetime lead exposure produces behavioral toxicity (spatial discrimination reversal) in adult monkeys
Toxicol. Appl. Pharmacol.
(1987) Environmental tobacco smoke: overview of chemical composition and genotoxic components
Mutat. Res.
(1989)Deficient activity of DPNH-dependent methemoglobin diaphorase in cord blood erythrocytes
Blood
(1963)- et al.
Mercury exposure from interior latex paint
N. Engl. J. Med.
(1990) - et al.
Methylmercury poisoning in Iraq
Science
(1973) - et al.
Prenatal prediction of risk of the fetal hydantoin syndrome
N. Engl. J. Med.
(1990) - et al.
Abnormal neuronal migration, deranged cerebral cortical organization, and diffuse white matter astrocytosis of human fetal brain: a major effect of methylmercury poisoning in utero
J. Neuropathol. Exp. Neurol
(1978)
Cited by (30)
Trace elements in children with autism spectrum disorder: A meta-analysis based on case-control studies
2021, Journal of Trace Elements in Medicine and BiologyCitation Excerpt :A previous study has shown that humans are sensitive to the toxicity of heavy metals in the environment, and children are more susceptible to the toxicity of heavy metals than adults. Meanwhile, the proportion of Pb absorbed by young children through the gastrointestinal tract is higher than that of adults [43]. An epidemiological study in the United States found that per thousand kilograms of Hg pollution increased the incidence of autism by 61 % [44].
Short-term effects of a perinatal exposure to a 16 polycyclic aromatic hydrocarbon mixture in rats: Assessment of early motor and sensorial development and cerebral cytochrome oxidase activity in pups
2014, NeuroToxicologyCitation Excerpt :Within these populations, young children are more vulnerable to the adverse effects of contaminants due to particularities of physiology and ways of interaction with the environment during the early phase of development (Landrigan et al., 2002; Sly and Flack, 2008). Actually, children breath more air and need more calories per body weight than adults, leading them to be exposed to proportionally higher amounts of contaminants (Graeter and Mortensen, 1996; Sly and Flack, 2008; Weiss and Landrigan, 2000). Furthermore, the increased sensitivity of the central nervous system to environmental agents during the early stages of development compared to the mature brain is currently well recognized (Landrigan et al., 2005; Miodovnik, 2011; Tilson et al., 1998).
Identifying important life stages for monitoring and assessing risks from exposures to environmental contaminants: Results of a World Health Organization review
2014, Regulatory Toxicology and PharmacologyCitation Excerpt :Table 1 illustrates different aspects of toxic substance exposure as described by Sexton et al. (1995). Again, the focus on children or childhood is highlighted in this paper because of their potential vulnerabilities (Bruckner, 2000; Graeter and Mortensen, 1996; Makri et al., 2004; Schwenk et al., 2003; Walker, 2005). “Although there is no single ‘correct’ set of age groups, adopting a common convention for defining age groups will enable scientists to better understand differences in exposure and risk across life stages and the factors that may account for such differences, such as nutritional status, prevalence of certain diseases, ethnic/cultural norms regarding activity or behavior patterns, population genetic characteristics, meteorological conditions, geography, and social stress” (Firestone, 2010).
Response to the letter to the editor by Maraver et al. (2012). Nicotine traces detected in bottled mineral water
2012, Science of the Total EnvironmentGeneric Assessment Criteria for human health risk assessment of potentially contaminated land in China
2009, Science of the Total EnvironmentBaseline chromosome aberrations in children
2007, Toxicology Letters