Research letterEffect of dietary seaweed preparations on 1,2-dimethylhydrazine-induced intestinal carcinogenesis in rats
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Seaweeds in Human Health
2016, Seaweed in Health and Disease PreventionFucoidan from turbinaria conoides: A multifaceted 'deliverable' to combat pancreatic cancer progression
2015, International Journal of Biological MacromoleculesCitation Excerpt :Recently, algal polysaccharides have been proven to possess various biological properties including antioxidant, anti-inflammatory, anticoagulant, antiviral and anti-tumor [15,23]. When mixed with animal diets, seaweed polysaccharides were found to inhibit cancer progression in experimental models [24]. In this context, this study was undertaken to evaluate the anti-tumor properties of fucoidans from the brown alga, Turbinaria conoides with respect to their antioxidant potential.
Marine resource: A promising future for anticancer drugs
2013, Studies in Natural Products ChemistryCitation Excerpt :Borophycin is related both to the boron-containing boromycins isolated from a terrestrial strain of Streptomyces antibioticus and to the aplasmomycins isolated from a marine strain of Streptomyces griseus (actinomycetes) [235]. There are many reports on the immunomodulating and antitumor activities of algae [236–247]. An extract from the brown seaweed Sargassum thunbergii has shown antitumor activity [248] and inhibition of tumor metastasis in the rat mammary adenocarcinoma cell (13762 MAT) [249].
Laminaria japonica as a food for the prevention of obesity and diabetes
2011, Advances in Food and Nutrition ResearchCitation Excerpt :Recently, seaweeds have been attracting attention as healthy foods that contain beneficial components, which may be useful for the prevention and treatment of lifestyle-related diseases. Thus far, extracts of Laminaria sp. have been reported to exhibit anticancer (Reddy et al., 1985; Yamamoto and Maruyama, 1985), antioxidative (Reddy et al., 1984), antiviral (Makarenkova et al., 2010), antiatherogenic (Matanjun et al., 2010), immunostimulatory (Jeong et al., 2006; Oomizu et al., 2006), and anti-inflammatory (Shiratori et al., 2005) effects. The modern tendency to consume nutritionally rich diets coupled with irrational dietary habits has contributed to the growth of lifestyle-related diseases such as obesity and diabetes.
Nutritional and digestive health benefits of seaweed
2011, Advances in Food and Nutrition ResearchCitation Excerpt :Studies carried out using the laboratory animal models revealed that some seaweed fibers are effective in controlling chemically induced gut cancer. Different diets consisting 0.05–0.2% seaweed powders of Eisenia bicyclis, Laminaria angustata, and P. tenera were tested in intestinal tumor-induced rats with potent intestinal carcinogen, 1,2-dimethylhydrazine, and after 20 days, the tumor incidence was clearly reduced at varying degrees (Yamamoto and Maruyama, 1985). Moreover, porphyran showed appreciable antitumor activity against Meth-A fibrosarcoma in rats (Noda, 1993).
Influence of Laminarin polysaccahrides on oxidative damage
2011, International Journal of Biological MacromoleculesCitation Excerpt :The pro-inflammatory effects of ROS include endothelial damage, formation of chemotactic factors, neutrophil recruitment, cytokines release, and mitochondrial impairment [1,5,6,8], all contributing to a “free radicals overload” and to oxidant–antioxidant imbalance. The epidemiological data are supported by rodent model studies demonstrating protective effects of dietary kelps and other red and green algae against mammary [9–11], intestinal [12–14] and skin carcinogenesis [15]. Moreover, cell culture and cell-free studies have begun to elucidate the mechanisms underlying the potential anticarcinogenic effects of seaweed constituents, such as the antimutagenicity of kelp and red algal extracts against breast and colon cancer inducers [16] as well as aflatoxin B1 and N-methyl-N′-nitro-N-nitroguanidine [17]; inhibition of hyaluronidase activity [18] and anti-inflammatory and -proliferative activities by a variety of red algal [19] and kelp extracts [20].