Elsevier

Neuroscience Letters

Volume 75, Issue 1, 20 March 1987, Pages 1-5
Neuroscience Letters

Forebrain and brainstem afferents to the arcuate nucleus in the rat: Potential pathways for the modulation of hypophyseal secretions

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Abstract

Doxorubicin, an anti-oncogenic agent, was used as a retrograde marker to identify arcuate nucleus afferent projections. Injections of this tracer into the arcuate nucleus indicated that the subfornical organ, the organum vasculosum of the lamina terminalis, the nucleus raphe dorsalis and median raphe send projections to the arcuate nucleus. Immunocytochemical procedures were used to demonstrate that the raphe projections to the arcuate nucleus are serotoninergic. This anatomical investigation provides evidence that neural pathways exist between forebrain body fluid and mineral nuclei, mesencephalic serotonin nuclei and the arcuate nuclei.

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Present address: Department of Physiology, City University of New York Medical School, 138th and Convent Street, New York City, NY 10031, U.S.A.

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