Comparison of inhibition of polymerisation of mammalian tubulin and helminth ovicidal activity by benzimidazole carbamates
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2022, Veterinary ParasitologyCitation Excerpt :In the current study, 50–57 % of the worm population in the untreated control groups were immature (luminal or tissue phase) and therefore had not attained reproductive maturity with egg laying. Egg counts basically reflect the adult female A. galli population and as such do not reflect anthelmintic effects on non-reproducing larval stages of the lifecycle which are typically more resistant to the effects of anthelmintics (Del Castillo et al., 1964; Lacey et al., 1987, 1990). Thus EECR methods can only be considered as a an indirect measure of anthelmintic efficacy against mature A. galli nematodes.
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2021, Veterinary ParasitologyCitation Excerpt :However, r-carvone did not prevent egg hatching, suggesting that stiffness is not a good marker for egg hatching; however, the stiffness of the eggshell is different in morula and larvae eggs (Costa-Junior et al., 2020). The egg hatch assay is generally referred to as an ‘ovicidal’ assay, where the eggs that fail to hatch are considered dead (Lacey et al., 1987). The common primary mechanism of action of benzimidazoles such as albendazole is the inhibition of the formation of microtubules, which are hollow structures formed by heterodimers of 〈- and ®-tubulins (Mandelkow and Mandelkow, 1990).
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