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Soluble mammalian epoxide hydratase: Action on juvenile hormone and other terpenoid epoxides

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Abstract

  • 1.

    1. A soluble epoxide hydratase from mouse liver or kidney converts juvenile hormone and two epoxide containing juvenoids to their respective diols faster than the microsomal epoxide hydratases.

  • 2.

    2. The soluble enzyme hydrates the two trisubstituted epoxides much faster than the tetrasubstituted epoxide.

  • 3.

    3. Analysis by gel filtration indicates an approximate mol. wt of 150,000 for the liver enzyme while isoelectric focusing indicates a pI of 4·9.

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Supported by grants AM-02818 from the National Institutes of Health, GB-27574 from the National Science Foundation and 73019 from The Rockefeller Foundation.

Former post-doctoral fellow of The Rockefeller Foundation. Present address: Department of Entomology, University of California, Riverside, CA U.S.A.

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