Short communicationSoluble mammalian epoxide hydratase: Action on juvenile hormone and other terpenoid epoxides☆
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Cited by (47)
CRISPR/Cas9-mediated inactivation of the phosphatase activity of soluble epoxide hydrolase prevents obesity and cardiac ischemic injury
2023, Journal of Advanced ResearchCitation Excerpt :Almost 30 years after its initial discovery [1,2], it was shown in 2003 that the mammalian soluble epoxide hydrolase (sEH), encoded by the EPHX2 gene, is a bifunctional protein that not only exhibits a C-terminal epoxide hydrolase activity (sEH-H) but also a lipid phosphatase activity on its N-terminal domain (sEH-P) (Fig. 1a) [3,4].
Humble beginnings with big goals: Small molecule soluble epoxide hydrolase inhibitors for treating CNS disorders
2019, Progress in NeurobiologyMammalian Epoxide Hydrolases
2018, Comprehensive Toxicology: Third EditionSoluble epoxide hydrolase: Gene structure, expression and deletion
2013, GeneCitation Excerpt :There is a critical need to follow up on these observations with experimental models in animals and clinical interventions in man. sEH was first identified through its activity on substrates such as juvenile hormone, as well as lipid epoxides such as epoxystearate (Hammock et al., 1976). Through gel filtration and the assessment of differential hydrolysis of epoxystearate, the epoxide hydrolase activity in soluble fractions was determined to be distinct from the microsomal fraction obtained from the liver and kidneys of mice (Gill and Hammock, 1979).
EH3 (ABHD9): The first member of a new epoxide hydrolase family with high activity for fatty acid epoxides
2012, Journal of Lipid ResearchMammalian Epoxide Hydrolases
2010, Comprehensive Toxicology, Second Edition
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Supported by grants AM-02818 from the National Institutes of Health, GB-27574 from the National Science Foundation and 73019 from The Rockefeller Foundation.
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Former post-doctoral fellow of The Rockefeller Foundation. Present address: Department of Entomology, University of California, Riverside, CA U.S.A.