Dehydration is the first step in the bioactivation of haloperidol to its pyridinium metabolite☆
References (9)
- et al.
Distribution, excretion and metabolism of neuroleptics of the butyrophenone type
Eur. J. Pharmacol.
(1967) - et al.
Chronic parkinsonism secondary to intravenous injection of meperidine analogues
Psychiatry Res.
(1979) - et al.
Identification of a potentially neurotoxic pyridinium metabolite of haioperidol in rats
Biochem. Biophys. Res. Commun.
(1990) - et al.
The metabolism of haloperidol
Curr. Ther. Res.
(1978)
There are more references available in the full text version of this article.
Cited by (57)
Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-Chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one
2008, Bioorganic and Medicinal ChemistryDetermination of 1-methyl-1,2,3,4-tetrahydroisoquinoline in mouse brain after treatment with haloperidol by gas chromatography-selected ion monitoring
1999, Journal of Chromatography B: Biomedical Sciences and ApplicationsOrphan neurones and amine excess: The functional neuropathology of Parkinsonism and neuropsychiatric disease
1998, Brain Research Reviews
- ☆
This paper is dedicated to Professor H. Oelschlager, Director of The Institute of Pharmaceutical Chemistry, University of Frankfurt, on the occasion of this 70th birthday.
Copyright © 1991 Published by Elsevier Ireland Ltd.