Journal of Chromatography B: Biomedical Sciences and Applications
Regular paperDetermination of berberine in plasma, urine and bile by high-performance liquid chromatography
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Fe<inf>3</inf>O<inf>4</inf>@p-Naphtholbenzein as a novel nano-sorbent for highly effective removal and recovery of Berberine: Response surface methodology for optimization of ultrasound assisted dispersive magnetic solid phase extraction
2016, TalantaCitation Excerpt :Therefore, developing a sensitive method for determination of Brb in plasma and urine is inevitable for evaluating the pharmacokinetics of Brb in human [25]. Despite the reported methods for determination of Brb in biological samples taken from rat, mice and rabbit [26–30], there are only few reports dealing with its determination in human plasma and urine samples by different instrumental methods such as LC-ESI-MS [31], capillary zone electrophoresis (CZE) [32], high performance liquid chromatography with UV detection (HPLC-UV) [33,34], and gas chromatography-MS (GC–MS) [35]. Due to the matrix complexity in biofluid samples and with regard to the trace amounts of Brb in human plasma, utilization of an extraction technique prior to instrumental analysis is suitable to improve the detection results by simultaneous sample clean-up and analyte enrichment.
Comparative pharmacokinetics of puerarin, daidzin, baicalin, glycyrrhizic acid, liquiritin, berberine, palmatine and jateorhizine by liquid chromatography-mass spectrometry after oral administration of Gegenqinlian decoction and active components alignment (ACA) to rats
2015, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences