Full paperAssay of paracetamol and its metabolites in urine, plasma and saliva of children with chronic liver disease
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Enhanced fluorimetric detection of diphenylpyraline HCl using micelle and cyclodextrin mediated approach: Spectrofluorimetric and micellar liquid chromatographic application for either single or combined formulation with caffeine and paracetamol
2023, Spectrochimica Acta - Part A: Molecular and Biomolecular SpectroscopySimultaneous quantitative determination of paracetamol and its glucuronide conjugate in human plasma and urine by liquid chromatography coupled to electrospray tandem mass spectrometry: Application to a clinical pharmacokinetic study
2012, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesCitation Excerpt :For the simultaneous determination of paracetamol and its metabolites, mainly HPLC methods have been described [10]. GC–MS methods using derivatization have also been reported, for instance by using trifluoroacetic anhydride as the derivatization agent and electron-capture negative-ion chemical ionization (ECNICI) [11] or extractive methylation [12], or electron-capture pentafluorobenzyl bromide [13,14]. However, most of these assays are complex and include the use of additives like ion pairing agents or require time-consuming sample preparation.
Determination of paracetamol: Historical evolution
2006, Journal of Pharmaceutical and Biomedical AnalysisMicrodialysis - Theoretical background and recent implementation in applied life-sciences
2005, European Journal of Pharmaceutical SciencesEvaluation of acetaminophen P-glycoprotein-mediated salivary secretion by rat submandibular glands
2004, Archives of Oral BiologyCitation Excerpt :In particular, for acetaminophen the constant S/P ratio is equal to unity as previously reported.1–9 This observation and the significant correlation found for the area under the concentration-time profile and half-life elimination time between values derived from venous plasma and saliva levels, has led to the use of saliva as a biological fluid for determining acetaminophen pharmacokinetics in bioavailability and bioequivalence studies.2,5,10–14 Usually, when considering a lipid-soluble acid such as acetaminophen, the S/P ratio could be predicted on the basis of the degree of ionization of the drug in both biological fluids.2,6,9
The quantification of paracetamol, paracetamol glucuronide and paracetamol sulphate in plasma and urine using a single high-performance liquid chromatography assay
2004, Journal of Pharmaceutical and Biomedical Analysis
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Present address: The Liver Unit, The Children's Hospital, Ladywood Middleway, Birmingham B16 8ET, UK.