Lymphatics and adipose tissue
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Lipedema: What we don't know
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2020, Journal of Plastic, Reconstructive and Aesthetic SurgeryCitation Excerpt :The term “lipo-lymphedema” is used to describe the combined pathology in this most advanced stage. Stasis of lymphatic tissue, on the other hand, is known to enhance fat disposition and hence a mutual interaction between adipose tissue and the lymphatic system exists.20,21 Lipedema is diagnosed based on clinical examination and patient history, ruling out differential diagnoses.
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2020, Surgical Oncology Clinics of North AmericaCitation Excerpt :Furthermore, it can have negative psychological and social impacts on patients.46 Preventive measures, including weight management and supervised exercise programs, have been shown to decrease the risk of lymphedema development.47 For those who develop lymphedema, prompt referral for decongestive therapy is the gold standard.48
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2018, Surgical Oncology Clinics of North AmericaCitation Excerpt :Clinical manifestations include nonpitting edema with overlying skin changes. Stasis of the protein-rich fluid makes the subcutaneous tissues prone to recurrent bacterial and fungal infections, which ultimately leads to progressive damage of the lymphatics.14 The enlarged and edematous limb can subsequently cause debilitating and chronic pain, decreased quality of life (QoL), psychosocial issues, increased infection risk, higher medical costs, and loss in productive days for those afflicted with the disease.15,16