Spermatotoxicity of dibromoacetic acid in rats after 14 daily exposures☆
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2019, Effects of Lifestyle on Men’s HealthThe Sertoli Cell as a Target for Toxicants
2018, Comprehensive Toxicology: Third EditionMethod to assess component contribution to toxicity of complex mixtures: Assessment of puberty acquisition in rats exposed to disinfection byproducts
2017, Journal of Environmental Sciences (China)Citation Excerpt :In the F1 generation, the authors reported no significant differences in age at PPS or VO in any dose group (p > 0.05). We note that other published reports on the effects of DBPs either on additional reproductive/developmental endpoints in S-D rats or in other in vivo experimental models (examples include the reported effects of bromochloroacetic acid, dichloroacetic acid and dibromoacetic on sperm in S-D rats (Klinefelter et al., 2002; Linder et al., 1994a, 1994b, 1997a, 1997b) are not reported here, as we focused on puberty attainment in the S-D rat. Narotsky et al. (2015) administered the DM, comprised of nine regulated DBPs, as drinking water to pregnant rats from GD 0 through weaning of their offspring; treatment of the F1 generation via drinking water continued to the end of the study.
Monohaloacetic acid drinking water disinfection by-products inhibit follicle growth and steroidogenesis in mouse ovarian antral follicles in vitro
2016, Reproductive ToxicologyCitation Excerpt :Several dihaloacetic acids alter intestinal microbial populations and their metabolism, which could lead to bioactivation of promutagens or procarcinogens in rats [26]. Dibromoacetic acid alters spermatogenesis and disrupts testicular steroidogenesis in male rats [27,28]. In addition, dibromoacetic acid disrupts estrous cyclicity and suppresses estradiol catabolism, which leads to alterations in steroid production in female rats [29,30].
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This paper has been reviewed by the Health Effects Research Laboratory, U.S. Environmental Protection Agency, and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.