Neuron
Volume 9, Issue 1, July 1992, Pages 69-77
ArticleA new conus peptide ligand for mammalian presynaptic Ca2+ channels
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Cited by (468)
A novel ω-conotoxin Bu8 inhibiting N-type voltage-gated calcium channels displays potent analgesic activity
2021, Acta Pharmaceutica Sinica BCitation Excerpt :ω-Conotoxins belong to a family of conotoxins and are usually composed of 25–40 amino acids folded with three disulfide bonds (C-C-CC-C-C)5. To date, 22 ω-conotoxins which inhibit L-(CaV1.1), N-(CaV2.2) and P/Q-type (CaV2.1) calcium channels have been characterized with several of these conotoxins specifically targeting CaV2.27–21. CaV2.2 is highly expressed in superficial layers of the spinal cord and dorsal root ganglion neurons and modulates pain and other physiological signal processing22–24.
Structure and allosteric activity of a single-disulfide conopeptide from Conus zonatus at human α3β4 and α7 nicotinic acetylcholine receptors
2020, Journal of Biological ChemistryFriends or Foes? Emerging Impacts of Biological Toxins
2019, Trends in Biochemical SciencesToxicology of the Neuromuscular Junction
2018, Comprehensive Toxicology: Third EditionBlock of voltage-gated calcium channels by peptide toxins
2017, Neuropharmacology
Copyright © 1992