Research reportMetabolite profiles in patients on high-dose valproate monotherapy
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Cited by (14)
Population pharmacokinetic modelling of valproic acid and its selected metabolites in acute VPA poisoning
2017, Pharmacological ReportsCitation Excerpt :The results are in agreement with our previous findings [5] based on Apple coefficients [27]. Sugimoto et al. [28] investigated metabolite profiles in children at high, yet therapeutic, doses and found that 4VPA concentrations increased proportionally to according to the VPA dose, while β-oxidation metabolites did not increase. Again, these results are in agreement with our conclusions.
Severe valproic acid poisoning
2004, ReanimationAssociation of valproic acid and 2-propyl-4-pentenoic acid concentrations with adverse reaction in 254 Chinese patients with epilepsy
2019, Journal of Central South University (Medical Sciences)Simultaneous determination of valproic acid and its hepatotoxic metabolite by gas chromatography-mass spectrometry
2015, Chinese Pharmaceutical JournalValproate
2009, The Treatment of Epilepsy: Third Edition
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