2 Liver function tests

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Abstract

For optimal timing of liver transplantation and for the evaluation of new pharmacotherapeutic options, objective modalities for estimating the liver's functional reserve and prognosis in an individual patient are highly desirable. In the past a number of tests and several scoring systems have been proposed and validated to varying degrees for this purpose. The issues still to be clarified include: (1) any observed prognostic value of individual quantitative function tests and of scoring systems must be validated in independent, large enough and well defined patient populations; (2) it must be prospectively defined which (serially performed) quantitative test(s) add(s) prognostic information for the individual patient to the survival estimates defined by the more universally available scores and in which disease state(s); and (3) existing scoring systems must be validated, or new ones developed, that allow follow-up data to be used in order to adapt the original prognosis estimate to the evolution of the disease, e.g. during therapy.

References (145)

  • YS Huang et al.

    Measuring lidocaine metabolite—monoethylglycinexylidide as a quantitative index of hepatic function in adults with chronic hepatitis and cirrhosis

    Journal of Hepatology

    (1993)
  • S Imaoka et al.

    Aminopyrine metabolism by multiple forms of cytochrome P450 from rat liver microsomes: simultaneous quantitation of aminopyrine metabolites by high-performance liquid chromatography

    Archives of Biochemistry and Biophysics

    (1988)
  • S Keiding

    Galactose clearance measurements and liver blood flow

    Gastroenterology

    (1988)
  • BA Lashner et al.

    Chronic hepatitis: Disease factors at diagnosis predictive of mortality

    American Journal of Medicine

    (1988)
  • BH Lauterburg et al.

    Hepatic functional deterioration after portocaval shunt in the rat

    Gastroenterology

    (1976)
  • B Meyer-Wyss et al.

    Assessment of lidocaine metabolite formation in comparison with other quantitative liver function tests

    Journal of Hepatology

    (1993)
  • M Oellerich et al.

    Lignocaine metabolite formation as a measure of pretransplant liver function

    Lancet

    (1989)
  • JG O'Grady et al.

    Early indicators of prognosis in fulminant hepatic failure

    Gastroenterology

    (1989)
  • R Adam et al.

    Limits of the MEGX test in the selection of liver grafts for transplantation

  • M Adler et al.

    Factors influencing survival at one year in patients with nonbiliary hepatic parenchymal cirrhosis

    Digestive Diseases and Sciences

    (1990)
  • N Aebli et al.

    Prognostische Wertigkeit der seriellen Bestimmung der Galaktose-Eliminationskapzität bei chronisch-aktiver Hepatitis

    Schweizerische Medizinische Wochenschrift

    (1991)
  • I Albers et al.

    Superiority of the Child-Pugh classification to quantitative liver function tests for assessing prognosis of liver cirrhosis

    Scandinavian Journal of Gastroenterology

    (1989)
  • A Arrigoni et al.

    Monoethylglycinexylidide test: A prognostic indicator of survival in cirrhosis

    Hepatology

    (1994)
  • PE Ballmer et al.

    Albumin synthesis rates in cirrhosis: correlation with Child-Turcotte classification

    Hepatology

    (1993)
  • MJ Bargetzi et al.

    Lidocaine metabolism in human liver microsomes by cytochrome P450111A4

    Clinical Pharmacology and Therapeutics

    (1989)
  • M Bergström et al.

    A simplified method to determine galactose elimination capacity in patients with liver disease

    Scandinavian Journal of Clinical and Laboratory Investigation

    (1993)
  • PD Berk et al.

    Bilirubin metabolism and the hereditary bilirubinemias

  • J Bernueau et al.

    Multivariate analysis of prognostic factors in fulminant hepatitis B

    Hepatology

    (1986)
  • W Berry et al.

    Bile acid metabolism: its relation to clinical disease

  • U Beuers et al.

    Prognostic value of the intravenous 14C-aminopyrine breath test compared to the Child-Pugh score and serum bile acids in 84 cirrhotic patients

    Digestion

    (1991)
  • J Bircher et al.

    Aminopyrine demethylation measured by breath analysis in cirrhosis

    Clinical Pharmacology and Therapeutics

    (1976)
  • RA Branch et al.

    Determinants of serum antipyrine half-lives in patients with liver disease

    Gut

    (1973)
  • KJ Breen et al.

    [14C]phenacetin breath test to measure hepatic function in man

    Hepatology

    (1984)
  • M Burdelski et al.

    A novel approach to assessment of liver function in donors

  • KM Carlisle et al.

    Estimation of hepatic blood flow by duplex ultrasound

    Gut

    (1992)
  • CG Child et al.

    Surgery and portal hypertension

  • E Christensen et al.

    Changes of laboratory variables with time in cirrhosis: prognostic and therapeutic significance

    Hepatology

    (1985)
  • JA Cohen et al.

    The SGOT/SGPT ratio—an indicator of alcoholic liver disease

    Digestive Diseases and Sciences

    (1979)
  • Deaciuc IV et al.

    Hyaluronic acid uptake by isolated perfused rat liver: an index of hepatic sinusoidal endothelial cell function

    Hepatology

    (1993)
  • PV Desmond et al.

    Impaired elimination of caffeine in cirrhosis

    Digestive Diseases and Sciences

    (1980)
  • ER Dickson et al.

    Prognosis in primary biliary cirrhosis: model for decision making

    Hepatology

    (1989)
  • M Dossing et al.

    Time course of phenobarbital and cimetidine mediated changes in hepatic drug metabolism

    European Journal of Clinical Pharmacology

    (1983)
  • A Engström-Laurent et al.

    Increased serum hyaluronate in liver disease

    Hepatology

    (1985)
  • M Farrant et al.

    Natural history and prognostic variables in primary sclerosing cholangitis

    Gastroenterology

    (1991)
  • A Frei et al.

    The N-terminal propeptide of collagen type III in serum reflects activity and degree of fibrosis in patients with chronic liver disease

    Hepatology

    (1984)
  • AR Gill et al.

    Aminopyrine breath test predicts surgical risk for patients with liver disease

    Annals of Surgery

    (1983)
  • P Gines et al.

    Compensated cirrhosis: natural history and prognostic factors

    Hepatology

    (1987)
  • DM Goldberg

    5′-nucleotidase: recent advances in cell biology, methodology and clinical significance

    Digestion

    (1973)
  • PM Grambsch et al.

    Extramural cross-validation of the Mayo primary biliary cirrhosis survival model establishes its generalizability

    Hepatology

    (1989)
  • SM Greenfield et al.

    Evaluation of postprandial serum bile acid response as a test of hepatic function

    Digestive Diseases and Sciences

    (1986)
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