Tumor necrosis factor receptor superfamily members and their ligands

https://doi.org/10.1016/0952-7915(94)90119-8Get rights and content

Abstract

The tumor necrosis factor (TNF) receptor family comprises a number of type 1 integral membrane glycoproteins which exhibit sequence homology in their cysteine-rich extracellular domains. Recently, ligands for many of these receptors have been identified. These molecules all display sequence identity with TNF and lymphotoxin β, prototype ligands for this receptor family, and have the conformation of type II transmembrane molecules. While certain biological activities are common to many members of this TNF-like family, other activities appear to be shared only by some ligands, or are unique. The identification of the TNF superfamily of ligands has provided the opportunity to compare and contrast the diverse biological effects mediated through the interaction of these related molecules with their receptors.

References (57)

  • B. Beutler

    Tumor Necrosis Factors The Molecules and Their Emerging Role in Medicine

    (1992)
  • R.G. Goodwin et al.

    Molecular Cloning and Expression of the Type 1 and Type 2 Murine Receptors for Tumor Necrosis Factor

    Mol Cell Biol

    (1991)
  • H. Engelmann et al.

    Two Tumor Necrosis Factor-Binding Proteins Purified from Human Urine. Evidence for Immunological Cross-Reactivity with Cell Surface Tumor Necrosis Factor Receptors

    J Biol Chem

    (1990)
  • T. Gatanaga et al.

    Purification and Characterization of an Inhibitor (Soluble Tumor Necrosis Factor Receptor) for Tumor Necrosis Factor and Lymphotoxin Obtained from the Serum Ultrafiltrates of Human Cancer Patients

    Proc Natl Acad Sci USA

    (1990)
  • Y.J. Liu et al.

    Mechanism of Antigen-Driven Selection in Germinal Centres

    Nature

    (1989)
  • H. Stein et al.

    The Expression of the Hodgkin's Disease Associated Antigen Ki-1 in Reactive and Neoplastic Lymphoid Tissue: Evidence that Reed-Sternberg Cells and Histiocytic Malignancies are Derived from Activated Lymphoid Cells

    Blood

    (1985)
  • C.A. Smith et al.

    A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins

    Science

    (1990)
  • I. Stamenkovic et al.

    A B-Lymphocyte Activation Molecule Related to the Nerve Growth Factor Receptor and Induced by Cytokines in Carcinomas

    EMBO J

    (1989)
  • D. Camerini et al.

    The T Cell Activation Antigen CD27 is a Member of the NGF/TNF Receptor Gene Family

    J Immunol

    (1991)
  • S. Mallet et al.

    Characterization of the MRC OX40 Antigen of Activated CD4 Positive T Lymphocytes — a Molecule Related to Nerve Growth Factor Receptor

    EMBO J

    (1990)
  • B.S. Kwon et al.

    cDNA Sequences of Two Inducible T-cell Genes

  • J. Banchereau et al.

    The CD40 Antigen and Its Ligand

    Annu Rev Immitnol

    (1994)
  • L.A. Gravestein et al.

    Cloning and Expression of Murinc CD27: Comparison with 4-1BB, An other Lymphocyte-Specific Member of the Nerve Growth Factor Receptor Family

    Eur J Immunol

    (1993)
  • W.A.M. Loenen

    Receptors and Ligands of the Nerve Growth Factor Receptor Gene Family

    Curr Top Genet

    (1994)
  • R.J. Armitage et al.

    CD40L: A Multi-Functional Ligand

    Semin Immunol

    (1993)
  • C.A. Smith et al.

    CD30 Antigen, a Marker for Hodgkin's Lymphoma, is a Receptor Whose Ligand Defines an Emerging Family of Cytokines with Homology to THF

    Cell

    (1993)
  • R.G. Goodwin et al.

    Molecular Cloning of a Ligand for the Inducible T-cell Gene 4-1BB: A Member of an Emerging Family of Cytokines with Homology to Tumor Necrosis Factor

    Eur J Immunol

    (1993)
  • J.L. Browning et al.

    Lymphotoxin β, a Novel Member of the TNF Family that Forms a Heteromeric Complex with Lymphotoxin on the Cell Surface

    Cell

    (1993)
  • Cited by (289)

    View all citing articles on Scopus
    View full text