The Journal of Steroid Biochemistry and Molecular Biology
Transport of dehydroepiandrosterone and dehydroepiandrosterone sulphate into rat hepatocytes
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Simultaneous determination of sex hormones and bile acids in rat plasma using a liquid chromatography-tandem mass spectrometry method
2023, Journal of Pharmaceutical and Biomedical AnalysisCitation Excerpt :Using the method, we found DHEA, a precursor of estrogens and androgens, was correlated with the majority of BA. Potential reasons for the correlation may include liver function changes caused by DHEA [16], competition for transporters on hepatocyte surfaces [27,29], or deactivation of the cytochrome P450 mediated synthesis [25,30]. In conclusion, we developed a novel LC-MS method that simultaneously measures 14 SH and 32 BA in rat plasma, and obtained some valuable information on the SH and BA metabolism in pregnant rats using the method.
Integration of hepatic drug transporters and phase II metabolizing enzymes: Mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites
2006, European Journal of Pharmaceutical SciencesC<inf>19</inf>-5-ene Steroids in Nature
2005, Vitamins and HormonesCitation Excerpt :No function for these high‐affinity DHEA‐binding proteins has been described. Reuter and Mayer (1995) found that the transport of DHEAS into hepatocytes involves a saturable, carrier‐mediated, energy‐requiring system that was inhibited by monensin, a sodium‐specific ionophore (Estrada‐O et al., 1967). In contrast, DHEA entry was not saturable and appears to penetrate by diffusion.
Evidence that dehydroepiandrosterone, DHEA, directly inhibits GnRH gene expression in GT1-7 hypothalamic neurons
2003, Molecular and Cellular EndocrinologyDehydroepiandrosterone activates endothelial cell nitric-oxide synthase by a specific plasma membrane receptor coupled to Gα<inf>i2,3</inf>
2002, Journal of Biological ChemistryCitation Excerpt :Many of these actions are reported at pharmacological concentrations, or with more prolonged incubations than we have used in our studies (60). In these situations the effects of lipophilic steroids on the plasma membrane (61-63) or the direct effects of intracellular steroid (64) may be of greater importance than in our study. Furthermore, many of the effects of high circulating levels of DHEA in vivo cannot be differentiated from the effects of DHEA metabolites, including estradiol or testosterone.