Research paperEffect of aging on mixed-function oxidation and conjugation by isolated perfused rat livers
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Ischemia-Reperfusion Injury is More Severe in Older Versus Young Rat Livers
2007, Journal of Surgical ResearchCitation Excerpt :IR is accompanied by significant metabolic changes, the release of reactive oxygen species (ROS), and a profound inflammatory response that is mediated chiefly by neutrophils [1–3]. Aging is associated with a number of functional and structural changes in the liver: decreased numbers of hepatocytes, increased size of hepatocytes, decreased canalicular bile flow, decreased rate of bile acid excretion, decreased number of mitochondria, morphological and functional alterations of mitochondria, and increased numbers of lysosomes and peroxisomes [4, 5]. In particular, aging is associated with impaired glycogen utilization, oxygen consumption, and biosynthetic function [6].
Effect of aging on liver functions - An experimental study in a perfused rat liver model
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2012, Drug Metabolism and Disposition
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