Ibuprofen in children with cystic fibrosis: Pharmacokinetics and adverse effects*
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Cited by (95)
Tobramycin and Colistin display anti-inflammatory properties in CuFi-1 cystic fibrosis cell line
2021, European Journal of PharmacologyCitation Excerpt :To investigate the pairing of Ibuprofen:Tobramycin on the anti-inflammatory effect of the combination treatment on LPS-stimulated CuFi-1 cells, two concentrations were chosen: a Low (Ibuprofen:Tobramycin, 10:300 μg/ml) and a High (Ibuprofen:Tobramycin, 100:3000 μg/ml) concentration. Both concentrations were chosen based on the cytotoxicity results (Fig. 3B–C) and on the fact that the peak plasma concentration of ibuprofen that gives the maximum therapeutic effect in vivo has been identified as 100 μg/ml (Konstan et al., 1991, 2003). As expected, cells treated with ibuprofen alone at both Low and High concentrations (shown as IBU, Fig. 5A) significantly decreased IL-8 production, when compared to untreated LPS-stimulated cells (shown as control, P < 0.01; two-way ANOVA, Fig. 5A).
Use of physiologically based pharmacokinetic models coupled with pharmacodynamic models to assess the clinical relevance of current bioequivalence criteria for generic drug products containing ibuprofen
2014, Journal of Pharmaceutical SciencesCitation Excerpt :One of the few cases where intestinal pH is less well regulated is in cystic fibrosis patients, who have impaired pancreatic and biliary HCO3− secretion, resulting in lower and highly variable small intestine pH values.82,83 The lower intestinal pH in these patients might explain the 30% reduction in ibuprofen Cmax observed in children with cystic fibrosis in comparison with healthy children.84 In general though, given the above-mentioned protective mechanisms extant in most volunteers and patient groups, it seems highly unlikely that a weakly acid drug would markedly change the in vivo small intestine microenvironment pH. Interestingly, although the final pH values of saturated solutions of ibuprofen are lowered by 2 units when solubility media of low-buffer capacity are used, as in the case of Hank’s balanced salt solution (buffer capacity = 1.6 mEq/L per pH unit), in which the pH changed from 7.56 to 5.52, a smaller reduction, around 1 pH unit, was observed in vivo, after perfusing a segment of rat intestine with ibuprofen solutions using the same media.
Bronchiectasis in Children
2009, Pediatric Clinics of North AmericaCitation Excerpt :An additional trial has reported similar findings.74 Severe gastrointestinal bleeding in less than 1% of patients receiving drug was considered an acceptable risk compared with the benefits of long-term use among patients who have mild pulmonary disease.75 Long-term oral steroid therapy has not been studied in idiopathic bronchiectasis.
Biocatalytic Insights for The Synthesis of New Potential Prodrugs: Design of two Ibuprofen Derivatives
2023, Applied Sciences (Switzerland)
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Supported by Cystic Fibrosis Foundation and National Institutes of Health grants P30-DK27651, T32-HL07415, and MO1 RR-00080.