1-Naphthol β-D-glucuronide formed intraluminally in rat small intestine mucosa and absorbed into the colon
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2015, Journal of Pharmaceutical and Biomedical AnalysisCitation Excerpt :Since hepatic glucuronide metabolites excreted into the bile cannot reenter the separated intestinal segment, reentering of the formed hepatic glucuronide metabolites via the systemic blood flow cannot be excluded [39]. Appearance of the glucuronides in the perfusate in a relatively short time, however, supports the intestinal conjugation of the compounds [40,41]. Similar results have been obtained while studying glucuronide formation of 4-nitrophenol under the same experimental conditions [38].
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2004, Biochemical and Biophysical Research CommunicationsCitation Excerpt :This phenomenon has already been demonstrated in human head and neck squamous carcinoma cells [29] and in undifferentiated human colonic carcinoma cells [30], but never in differentiated human colonic epithelial cells. Other enzymes were for the first time identified by microarrays as potential targets of butyrate, one UDP-glucuronosyltransferase (UGT1A6) involved in colonic lumen compounds detoxification [31] class K glycosylphosphatidylinositol, (GPI) surface protein (PIGK) and (Dol-P-man flippase) SL15, both involved in GPI anchorage [32–34], and protein–N-glycanase (PNGase), which cleaves protein–N-glycan linkage. Real time PCR revealed that butyrate modulating effects reached statistical significance only for three enzymes: galectin-1, α2,3-sialyltransferase V, and Dol-P-man flippase.
Diets supplemented with fiber do not increase accumulation of 1-naphthol
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2002, Biochemical PharmacologyCitation Excerpt :MRP3 expression appears to be upregulated when MRP2 is genetically absent [12]. Moreover, the level of expression of transporters appears to differ in the small intestine and colon; for example, in inverted rat intestinal sacs 1-naphthol glucuronide (which may be transported similar to MUF-GA) was secreted in the small intestine mostly at the apical surface, whereas it was basolaterally secreted in the colon [27]. Transporters such as the apical export pump MRP2 and the basolateral export pump MRP3 clearly determine the site of secretion of glucuronides, for example into the lumen of the intestine or into the portal blood [12–14].