Efficient Asymmetric Synthesis of the Four Diastereomers of Diphenacoum and Brodifacoum
Section snippets
EXPERIMENTAL
1H NMR spectra were recorded at ambient temperatures on a Bruker AM-300 spectrometer for solutions in CDCl3 or C6D6 with Me4Si as internal standard. IR spectra were recorded on a Unicam SP 100 spectrophotometer, using 0.1 cm sodium chloride solution cells. High and low resolution mass spectra were obtained on a Kratos MS-80 mass spectrometer. Melting points were measured on a Reichert hot-stage apparatus and are uncorrected. CD measurements were obtained for solutions in MeOH on a Jasco J-710
Acknowledgements
Financial support by the Foundation for Research Development, Pretoria and the ‘Sentrale Navorsingsfonds’ of this University is gratefully acknowledged.
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