Methods for routine biological monitoring of carcinogenic PAH-mixtures
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Cited by (109)
Exposure to polycyclic aromatic hydrocarbons assessed by biomonitoring of firefighters during fire operations in Germany
2023, International Journal of Hygiene and Environmental HealthUrinary polycyclic aromatic hydrocarbon metabolites among 3-year-old children from Krakow, Poland
2018, Environmental ResearchCitation Excerpt :This observation is in line with other studies conducted in pediatric populations that analyzed OH-PAHs in addition to 1-OH-PYR (Fan et al., 2012a; Li et al., 2008; Oliveira et al., 2017). 1-OH-PYR is the most frequently analyzed PAHs metabolite and is considered a relevant biomarker of both occupational and ambient air exposure (Hansen et al., 2008; Jongeneelen, 1997). The average urine concentration of 1-OH-PYR in our study was much higher than levels reported in most other studies conducted in preschool children in different parts of the world (Chuang et al., 1999; Grainger et al., 2005; Kang et al., 2002; Li et al., 2008; Mori et al., 2011); and, compared to other European pediatric populations, our levels were more than twice as high (Fiala et al., 2001; Freire et al., 2009; Hansen et al., 2006; Heudorf and Angerer, 2001; Lange and Eis, 2004; Oliveira et al., 2017) (See Supplemental Table 6.).
Urinary trans-anti-7,8,9,10-tetrahydroxy-7,8,9,10-tetrahydrobenzo(a)pyrene as the most relevant biomarker for assessing carcinogenic polycyclic aromatic hydrocarbons exposure
2018, Environment InternationalCitation Excerpt :Biomonitoring of exposure taking into account all absorption routes, occupational and leisure exposure, and personal protective equipment efficiency, is more accurate than atmospheric PAH measurements. PAH metabolites are largely used as exposure biomarkers (Brandt and Watson, 2003; Jongeneelen, 1997). These metabolites are conjugated to sulfate or glucuronic acid before their excretion in feces and urine (Jacob and Seidel, 2002).
Screening for DNA adducts in ovarian follicles exposed to benzo[a]pyrene and cigarette smoke condensate using liquid chromatography-tandem mass spectrometry
2017, Science of the Total EnvironmentCitation Excerpt :Therefore, human exposure to PAHs is a matter of concern. Human exposure to PAHs is mainly from occupation, passive and active smoking, food and water, and air pollution (Jongeneelen, 1997; ACGIH, 2005; Hashim and Boffetta, 2014; Shen et al., 2014). The total intake of carcinogenic PAHs in the United States population was estimated to be about 3 mg/day (Mumtaz et al., 1996).
Investigation on the interaction of pyrene with bovine serum albumin using spectroscopic methods
2014, Spectrochimica Acta - Part A: Molecular and Biomolecular SpectroscopyCitation Excerpt :PAHs in the environment arise principally from the combustion of fossil fuels, industrial emissions (e.g. coke oven plants, cement plants, incinerators, aluminum industries), mobile sources (e.g. automobile and aircraft exhaust) and forest fires [1]. Since the pyrene metabolites, 1-hydroxypyrene (1-OHP) and its glucuronide conjugate, are used as the most common biomarker for recent PAH exposures [2–4], and pyrene occurs at relatively high concentrations in PAH mixtures [5,6], this chemical is an important toxicological agent of major concern. However, the toxicity produced by it direct interaction with biological macromolecules in vivo has not been explored previously.
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