Pharmacokinetics and pharmacodynamics of clomethiazole after oral and rectal administration in healthy subjects
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Intramuscular and rectal therapies of acute seizures
2015, Epilepsy and BehaviorCitation Excerpt :Area under the concentration–time curve values were similar after administration by both routes. Relative rectal bioavailability was 90% compared with oral administration [77]. Thus, at this time, only MZD given intramuscularly and DZP given rectally appear to have the properties required for rapid enough absorption to be useful when IV routes are not possible.
Selective time-And NADPH-Dependent inhibition of human CYP2E1 by clomethiazole
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