Ontogenic expression of the Na+-independent organic anion transporting polypeptide (oatp) in rat liver and kidney
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Role of nuclear receptors for bile acid metabolism, bile secretion, cholestasis, and gallstone disease
2011, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :Divalent bile acids with two negative charges such as sulfated tauro- or glycolithocholate are transported by multidrug resistance-associated protein MRP2 (ABCC2) (Fig. 2) [130]. MRP2 also mediates the excretion of a broad range of other non-bile acid organic anions, mostly conjugates with glutathione, glucuronidate, and sulfate formed by phase II conjugation in the hepatocyte and of reduced glutathione (GSH) [130–133]. Additional transport systems in the canalicular membrane include a multidrug export pump (MDR1) for amphipathic organic cations [134,135] (e.g., various drugs), a phospholipid floppase (MDR3/MDR2 in rodents) for phosphatidylcholine translocation [136,137], the cholesterol two half-transporters ABCG5/8 for sitosterol and cholesterol export [138–140] (Fig. 2), a P-type ATPase (FIC1; ATP8B1) mutated in hereditary cholestasis [141,142], and an Cl−/HCO3− anion exchanger 2 (SLC4A2, AE2) [143,144], all of them involved in bile formation.
Differential expression of bile salt and organic anion transporters in developing rat liver
2004, Journal of HepatologyHeterogeneity of rat liver parenchyma in taurocholate uptake
2003, Hepatology ResearchPharmacokinetics in the newborn
2003, Advanced Drug Delivery ReviewsSensitivity of bile acid transport by organic anion-transporting polypeptides to intracellular pH
2003, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :From studies using basolateral plasma membrane vesicles from fetal rat liver, functional evidence for sodium-independent bile acid transport activity preceding that for sodium-dependent mechanisms has been found [9]. This is consistent with molecular biology studies reporting that the gene transcription of rat Oatp1(Slc21a1) in the fetal liver precedes that of Ntcp (Slc10a1) [3,10]. Similarly, the intestinal sodium-dependent bile acid transport system also appears late in ontogenic development [11,12].