Consumption of quercetin and kaempferol in free-living subjects eating a variety of diets
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2019, Phytochemicals as Lead Compounds for New Drug DiscoveryIn vitro and in vivo anticancer efficacy potential of Quercetin loaded polymeric nanoparticles
2018, Biomedicine and PharmacotherapyCitation Excerpt :Quercetin(QCT) is one of the flavonoid derived from many plants, has shown anticancer potential and has been entered in phase-1 clinical trial [28]. QCT is ubiquitously present in many medicinal plants, fruits, vegetables and red wine [29,30]. It has been reported that QCT can inhibit the growth of cancer cells [31,32], prevent metastasis by inhibiting secretion of matrix metalloproteinases (MMPs) [33], inhibit epigenetic modifications [34], induce cell cycle arrest [35] and apoptosis [36,37], prevent oxidative stress [30,38,39] and inhibit angiogenesis [40,41] in tumour tissue (Fig. 1).
Therapeutic potential of quercetin as a cardiovascular agent
2018, European Journal of Medicinal ChemistryCitation Excerpt :Other risk factors like platelet thromboxane B2 production, resting heart rate, aggregation of platelets and blood pressure also shows no improvement. The research also exposed that there was no impact of quercetin supplements on the polyunsaturated body fat stages in the serum [36] Conquer & Maiani concluded with experimental evidence that quercetin-containing capsules could enhance its concentration in the plasma, but it has no effects on risk factors associated with cardiovascular diseases [37]. Rendig et al. [38] later incorporated a dynamic study on the concentration of quercetin in the blood, which suggested endothelium-independent vasorelaxation of the coronary vessels due to higher levels of quercetin in animal models.
Rapid determination of 3′ 4′-dimethoxy flavonol-3-β-D-glucopyranoside in rat plasma by LC-MS/MS method followed by protein precipitation
2018, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesCitation Excerpt :Some epidemiological studies suggested that a high intake of dietary flavonoids was beneficial to preventing cardiovascular disease [21] and cancer [22–26]. Jeanne H.M. de Vries [27] estimated a daily total dietary flavonoid intake of approximately 28 mg had very low toxicity in humans. Flavonoids are present mainly as glycosides whose phenolic hydrogen or hydrogens are substituted to sugar moiety [28].