Effects of the selective metabotropic glutamate agonist LY354740 in a rat model of permanent ischaemia
References (15)
- et al.
In vivo inhibition of veratridine-evoked release of striatal excitatory amino acids by the group II metabotropic glutamate receptor agonist LY354740 in rats
Neurosci. Lett.
(1997) - et al.
The inhibitory mGluR agonist, S-4-carboxy-3-hydroxy-phenylglycine selectively attenuates NMDA neurotoxicity and oxygen-glucose deprivation-induced neuronal death
Neuropharmacology
(1995) - et al.
Activation of metabotropic glutamate receptor is neuroprotective during nitric oxide toxicity in primary hippocampal neurons of rats
Neurosci. Lett.
(1995) - et al.
Aniticonvulsive and neuroprotective actions of a potent agonist (DCG-IV) for group II metabotropic glutamate receptors against intraventricular kainate in the rat
Neuroscience
(1997) - et al.
Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders?
Trends Neurosci.
(1996) - et al.
The metabotropic glutamate receptors: structure and functions
Neuropharmacology
(1995) - et al.
LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors
Neuropharmacology
(1997)
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Preconditioning effect of (S)-3,5-dihydroxyphenylglycine on ischemic injury in middle cerebral artery occluded Sprague-Dawley rats
2015, Neuroscience LettersCitation Excerpt :These observations are consistent with the serum NSE of 1 μM and 10 μM (S)-3,5-DHPG preconditioning which were significantly lower than in the untreated stroke rats. It has been proposed that necrosis, apoptosis and ischemic preconditioning shared similar initial signaling pathway which depend on the intensity of an ischemic insult that being posed to the brain [32,33]. The reduction of brain damages in 1 and 10 μM (S)-3,5-DHPG preconditioning has been evidenced by other studies that suggested medium intensity of a stimulus commits the pathway to programmed cell protection.
Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic?
2012, Neurochemistry InternationalCitation Excerpt :It was logical to expect a robust protective activity of dual orthosteric mGlu2/3 receptor agonists against ischemic neuronal damage, which is largely mediated by extracellular glutamate (reviewed by Meldrum, 1990; Siesjö et al., 1995; Lipton, 1999). Neuroprotection was consistently seen in models of transient global ischemia (Henrich-Noack et al., 1998; Bond et al., 1998; Bond et al., 1999, 2000; Yoshioka et al., 2009), but, surprisingly, was completely absent in models of focal ischemia (Lam et al., 1998; Bond et al., 1999), where the role of extracellular glutamate in the pathophysiology of neuronal damage is more prominent. The ambiguity of these findings has stimulated an in-depth analysis of the individual role played by mGlu2 and mGlu3 receptors in mechanisms of neurodegeneration/neuroprotection.
The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2
2010, Bioorganic and Medicinal Chemistry LettersRegioselective synthesis of dispiro[1H-indene-2,3′-pyrrolidine-2′,3″-[3H]indole]-1,2″(1″H)-diones of potential anti-tumor properties
2009, European Journal of Medicinal ChemistryCitation Excerpt :Additionally, other derivatives were reported as allosteric potentiators of the metabotropic glutamate subtype 2 receptor (mGluR2) [31]. Agents targeting mGluR2 may have utility in a variety of clinical conditions [32–34], including epilepsy, anxiety and schizophrenia [35]. Reaction of 2-(arylmethylene)-2,3-dihydro-1H-inden-1-ones 1a–g with non-stabilized azomethine ylides, generated in situ via decarboxylative condensation of sarcosine (3) “as a representative example of α-amino acid” and isatins 2a,b in refluxing ethanol afforded only one product as indicated by TLC in a highly regioselective manner (Scheme 2).
Biphenyl-indanones: Allosteric potentiators of the metabotropic glutamate subtype 2 receptor
2005, Bioorganic and Medicinal Chemistry Letters3-(2-Ethoxy-4-{4-[3-hydroxy-2-methyl-4-(3-methylbutanoyl)phenoxy]butoxy} phenyl)propanoic acid: A brain penetrant allosteric potentiator at the metabotropic glutamate receptor 2 (mGluR2)
2005, Bioorganic and Medicinal Chemistry Letters