4 Desferrioxamine-induced iron excretion in humans
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Cited by (59)
Galangin mitigates iron overload-triggered liver injury: Up-regulation of PPARγ and Nrf2 signaling, and abrogation of the inflammatory responses
2021, Life SciencesCitation Excerpt :Although decreased duodenal iron absorption by hepcidin may prevent exacerbation of iron overload, it is unlikely to be the sole mechanism underlining the observed reduction in liver iron content. Other potential mechanisms may include redistribution of iron, for example, to the spleen or increased excretion of iron possibly in a way similar to that induced by deferoxamine [64,65]. These possibilities may be the subject of a future study to elucidate the exact underlining mechanisms.
Iron homeostasis and toxicity in retinal degeneration
2007, Progress in Retinal and Eye ResearchEvaluation of myocardial iron by magnetic resonance imaging during iron chelation therapy with deferrioxamine: Indication of close relation between myocardial iron content and chelatable iron pool
2003, BloodCitation Excerpt :At the beginning of treatment the DFO dose response was studied in 13 patients (except patient 12). Increasing doses of DFO (from 1 to 4 g) were given by 12-hour subcutaneous infusion on successive days with 24-hour collection of urine from the beginning of each infusion.21 In patient 7 iron excretion was only measured after 2 g DFO, and in patient 8 not after 4 g.
Total synthesis and structure revision of petrobactin
2003, TetrahedronHBED ligand: Preclinical studies of a potential alternative to deferoxamine for treatment of chronic iron overload and acute iron poisoning
2002, BloodCitation Excerpt :DFO is inefficient as an iron chelator; typically only 5% or less of the drug administered promotes iron excretion. Because gastrointestinal absorption is poor and circulatory elimination is rapid, effective therapy for chronic iron overload usually requires subcutaneous (SC) or IV administration by a portable infusion pump for 9 to 12 hours for 5 or 6 days each week.8-10 Not surprisingly, most patients have difficulty in complying with such a demanding regimen.
Monitoring chelation therapy to achieve optimal outcome in the treatment of thalassaemia
2002, Best Practice and Research: Clinical Haematology