Roles of the JAK-STAT system in signal transduction via cytokine receptors
References (54)
- et al.
JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following EPO stimulation
Cell
(1993) - et al.
The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor βc chain
J Biol Chem
(1995) - et al.
The conserved box 1 motif of cytokine receptors is required for association with JAK kinases
J Biol Chem
(1995) - et al.
Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals
Cell
(1995) - et al.
Kinase-negative mutants of JAK1 can sustain interferon-γ-inducible gene expression but not an antiviral state
EMBO J
(1996) - et al.
Functional activation of Jak1 and Jak3 by selective associates with IL-2 receptor subunits
Science
(1994) - et al.
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
Cell
(1995) - et al.
Requirement for MAP kinase (ERK2) activity in interferon α- and interferon β-stimulated gene expression through STAT proteins
Science
(1995) - et al.
Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)
Nature
(1995) - et al.
Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21WAF1/CIP1 mediated by STAT1
Science
(1996)
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
Nature
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
Science
Function of Stat2 protein in transcription activation by alpha interferon
Mol Cell Biol
JAK2 associates with the βc chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region
Mol Cell Biol
Molecular characterization of an alpha interferon receptor 1 subunit (IFNαR1) domain required for TYK2 binding and signal transduction
Mol Cell Biol
Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1
Mol Cell Biol
Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of Jak2
J Biol Chem
JAK2 is essential for activation of c-fos and c-myc promoters and cell proliferation through the human granulocyte—macrophage colony-stimulating factor receptor in BA/F3 cells
J Biol Chem
STATs: signal transducers and activators of transcription
Cell
A novel STAT-like factor mediates lipopolysaccharide, interleukin 1 (IL-1), and IL-6 signaling and recognizes a gamma interferon activation site-like element in the IL1B gene
Mol Cell Biol
Components of a Stat recognition code: evidence for two layers of molecular selectivity
Immunity
The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-α signals
EMBO J
Differentiation-regulated serine phosphorylation of STAT1 promotes GAF activation in macrophages
Mol Cell Biol
Role of STAT2 in the alpha interferon signaling pathway
Mol Cell Biol
Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development
Science
Defective lymphoid development in mice lacking Jak3
Science
Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3
Science
Cited by (70)
Antitumor and immunomodulatory effects of a water-soluble polysaccharide from Lilii Bulbus in mice
2014, Carbohydrate PolymersCitation Excerpt :IL-2 has many immunopotentiating effects, such as proliferation of T cells, B cells, NK cells and monocytes, augmentation of cytotoxicities of T cells and NK cells and in vivo generation of lymphokine-activated killer (LAK) cells, which exhibit high cytolytic activities against autologous tumor cells. IL-2 modulates IL-12 signaling through JAK-STAT pathway leading to the development of Th1 response (Kisseleva, Bhattacharya, Braunstein, & Schindler, 2002; Liu, Gaffen, & Goldsmith, 1998; Watanabe & Arai, 1996). As shown in Fig. 3, the serum levels of TNF-α and IL-12 in the model control mice were significantly increased while IL-2 and IL-6 were significantly decreased owing to the transplanted tumor (P < 0.01).
Loss of Jak2 impairs endothelial function by attenuating Raf-1/MEK1/Sp-1 signaling along with altered eNOS activities
2013, American Journal of PathologyExpression and characterization of a constitutively active STAT6 from Tetraodon
2010, Fish and Shellfish ImmunologyCitation Excerpt :Signal transducers and activators of transcription (STATs) are a family of transcription factors that exist in a latent state in cytoplasm; they are activated in response to various extracellular polypeptide ligands such as cytokines, growth factors, and hormones. Activated STAT proteins accumulate in the nucleus to drive transcription [1–4]. In mammals, there are seven STAT proteins with different functions [5].
Interferon regulatory factor (IRF)-2 activates the HPV-16 E6-E7 promoter in keratinocytes
2010, VirologyCitation Excerpt :A complex array of signal transduction pathways have been shown to modulate transcription from viral and cellular genes by multiple mechanisms (Brivanlou and Darnell, 2002) and a range of cytokines, growth factors and steroid hormones have been shown to modulate the activity of HPV promoters (Chan et al., 1989; Peto et al., 1995; Woodworth, Notario, and DiPaolo, 1990). We noted that the HPV-16 P97, pIRF-1 and pIRF-2 promoters are stimulated by IL-6, EGF or TGF-beta1 treatment (data not shown), indicating that multiple external factors can activate distinct signal transduction pathways (Leaman et al., 1996; Watanabe and Arai, 1996) to modulate early HPV gene expression in keratinocytes. These results suggest that multiple signal transduction pathways converge at the HPV-16 IRE possibly in the form of alternate induced IRE-binding complexes or via induction of additional cellular factors bound to other cis control elements in the complex major early promoter which in turn cooperate with IRF-2 bound to the IRE to drive early HPV gene expression.
Dimerization-based homogeneous fluorosensor proteins for the detection of specific dsDNA
2008, Biosensors and BioelectronicsIschemic preconditioning-induced expression of gp130 and STAT3 in astrocytes of the rat hippocampus
2004, Molecular Brain Research