The Journal of Steroid Biochemistry and Molecular Biology
Transcriptional regulation by HNF-4 of the steroid 15α-hydroxylase P450 (Cyp2a-4) gene in mouse liver
References (25)
- et al.
Transcriptional control in hepatocytes: a window on development
Trends in Biochemical Science
(1991) - et al.
Transcriptional regulatory element for basal expression of cytochrome P450IIC gene
Journal of Biological Chemistry
(1992) - et al.
A transcriptional regulatory element to a large family of hepatic cytochrome P450 genes is a functional binding site of the orphan receptor HNF-4
Journal of Biological Chemistry
(1994) - et al.
The structure and characterization of type I P45015α gene as major steroid 15α-hydroxylase and its comparison with type II P45015α gene
Journal of Biological Chemistry
(1989) - et al.
Gene family of male-specific testosterone 16α-hydroxylase (C-P45016α) in mice: organization, differential regulation, and chromosome localization
Journal of Biological Chemistry
(1989) - et al.
A specific cis-acting element regulates in vitro transcription of sex-dependent mouse steroid 16α-hydroxylase (C-P45016α) gene
Journal of Biological Chemistry
(1990) DNA methylation and gene activity
Cell
(1988)The essentials of DNA methylation
Cell
(1992)- et al.
Tissue-specific in vitro transcription from the mouse albumin promoter
Cell
(1986) - et al.
The rat P4502E1 gene: complete intron and exon sequence, chromosome mapping, and correlation of developmental expression with specific 5′ cytosine demethylation
Journal of Biological Chemistry
(1988)
Mechanisms of liver-specific gene expression
Current Opinion in Genetics and Development
Role of the liver-enriched transcription factor DBP in expression of the cytochrome P450 CYP2C6 gene
Molecular and Cellular Biology
Cited by (28)
Role of epigenetics in liver-specific gene transcription, hepatocyte differentiation and stem cell reprogrammation
2009, Journal of HepatologyCitation Excerpt :They also promote ALB synthesis and secretion rate, ammonia removal and gap junctional intercellular communication [2,11,50–52] (Table 1). DNA methylation marks, on the other hand, are crucial for developmental and tissue-specific transcription of numerous liver-specific genes, including ALB [132], AFP [133], Cx43 [134], Cx32 [134], human CYP2E1 [135], human CYP1A2 [136], rat CYP2D3 and CYP2D5 [137], mouse CYP2D9 [138], mouse CYP2A4 [139], and human SULT1A1 [140]. In addition, in HepG2 cells, CYP3A4, CYP3A5 and CYP3A7 levels were raised upon DNMT inhibition by 5-Aza-dC, whilst C/EBPβ and C/EBPγ were decreased.
Altered gene expression in mouse livers after dichloroacetic acid exposure
2003, Mutation Research - Reviews in Mutation ResearchRegulation of P450 genes by liver-enriched transcription factors and nuclear receptors
2003, Biochimica et Biophysica Acta - General SubjectsInduction of nuclear transcription factors, cytochrome P450 monooxygenases, and glutathione S-transferase alpha gene expression in Aroclor 1254-treated rat hepatocyte cultures
2001, Biochemical PharmacologyCitation Excerpt :It is intriguing that expression of transcription factor genes can be highly modulated by Aroclor 1254, but further experiments are needed to draw firm conclusions regarding the mechanisms underlying these events. Although there is limited information on the genome-wide number of target genes regulated by individual transcription factors, it has been shown that CYP1A2, CYP2C13, and CYP2E1 have common binding sites for HNF-1 [18,20,28] and similarly, that HNF-4 regulates, at least in part, CYP2A4, CYP2D6, CYP2C9, CYP2C13, and CYP3A1[21,24,30–32]. With the exception of CYP4A1, binding sites for c/EBPα are common to all CYP isozymes investigated in this study [17,19,20,22,23,29] and transcription factors may play a dual role in target gene expression as shown in the case of HNF-4, where expression of CYP2C13 can be negatively regulated by this particular transcription factor [29].