Dual metalloprotease inhibitors. I. constrained peptidomimetics of mercaptoacyl dipeptides

doi:10.1016/S0960-894X(01)80372-3

Bioorganic & Medicinal Chemistry Letters

Volume 4, Issue 15, 11 August 1994, Pages 1789-1794

https://doi.org/10.1016/S0960-894X(01)80372-3 Get rights and content

Abstract

A series of benzo-fused lactams were incorporated as conformationally restricted dipeptide mimetics of Ala-Pro in dual-acting ACE/NEP inhibitors 1 and 2. The result of this modification led to compounds possessing excellent inhibitory potency versus ACE and NEP both in vitro and in vivo.

A series of benzo-fused lactams were incorporated as conformationally restricted dipeptide mimetics of Ala-Pro in angiotensin converting (ACE)/neutral endopeptidase (NEP) inhibitors.

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Dual metalloprotease inhibitors. I. constrained peptidomimetics of mercaptoacyl dipeptides

Abstract

Life Sci.

Physiol. Rev.

C. R. Soc. Biol.

Pharm. Rev.

Kidney Internat.

Life Sci.

Proc. Natl. Acad. Sci. USA

Biochem. Soc. Trans.

J. Med. Chem.

J. Med. Chem.

J. Med. Chem.

Pept.: Struct. Funct., Proc. Am. Pept. Symp., 8th

Pept.: Struct. Funct., Proc. Am. Pept. Symp., 8th

Biochem. Biophys. Res. Comm.

J. Med. Chem.

J. Med. Chem.

Actual. Chim. Ther.

Chem. Pharm. Bull.

J. Chem. Soc., Perkin Trans. I

Chem. Pharm. Bull.

J. Med. Chem.

J. Am. Chem. Soc.

Heart Dis. Stroke

Bioorg. Med. Chem. Lett.

J. Med. Chem.

J. Med. Chem.

J. Med. Chem.

Curr. Opin. Invest. Drugs

J. Med. Chem.

J. Cardiovasc. Pharm.

FASEB J

J. Pharmacol. Exp. Ther.

J. Pharmacol. Exp. Ther.

Pharmacol. Exp. Ther.