Novel antineoplastic agents with efficacy against multidrug resistant tumor cells

doi:10.1016/S0960-894X(98)00477-6

Bioorganic & Medicinal Chemistry Letters

Volume 8, Issue 19, 6 October 1998, Pages 2653-2656

https://doi.org/10.1016/S0960-894X(98)00477-6 Get rights and content

Abstract

A novel series of pentafluorobenzenesulfonamides has been shown to inhibit the growth of a variety of human tumor cell lines. Among the cell types against which these agents were evaluated were the multidrug resistant (MDR) cell lines MCF-7/ADR and P388/ADR. The cytotoxic activity of members of this series of compounds was not affected by the multidrug resistant pump in MCF-7/ADR or P388/ADR cells.

This article reports the discovery of a novel series of pentafluorobenzenesulfonamides as cytotoxic agents with efficacy againt a broad variety of human tumor cell lines, including those that exhibit the MDR phenotype.

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Novel antineoplastic agents with efficacy against multidrug resistant tumor cells

Abstract

Cancer Res.

J. Natl. Cancer Inst.

J. Med. Chem.

J. Natl. Cancer Inst.

J. Med. Chem.

J. Med. Chem.

Anti-cancer Drug Design