Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: Insights into specificity and potency
Under a Creative Commons license
open archive
Two structurally related epoxyketone-containing natural products, epoxomicin (1) and dihydroeponemycin (2), display differential antiproliferative activity, proteasome subunit binding specificity, and rates of proteasome inhibition. To understand these differences, we report here the synthesis and characterization of epoxomicin/dihydroeponemycin chimerae.
Cited by (0)
Copyright © 1999 Published by Elsevier Ltd.