LetterMild trimethylaminuria observed in a Japanese cohort with liver damage
References (6)
- et al.
Mild trimethylaminuria caused by common variants in FMO3 gene
Lancet
(1999) - et al.
Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patients
Life Sci
(2004) - et al.
Two novel single nucleotide polymorphisms (SNPs) of the FMO3 gene in Japanese
Drug Metab Pharmacokinet
(2003)
Cited by (13)
Treatments of trimethylaminuria: where we are and where we might be heading
2020, Drug Discovery TodayCitation Excerpt :Treatment with choline in Huntington’s and Alzheimer’s diseases has been associated with the development of a strong fishy body odor [26,27], and is a classic example of precursor overload where the enzyme is unable to completely oxidize the TMA burden. Liver failure and portosystemic shunting of the blood can also result in increased TMA levels, owing to interference with first-pass metabolism [28,29]. Other factors that have been reported to cause or exacerbate the condition (including primary TMAU) encompass menstruation [30,31], asymptomatic viral hepatitis [32] and testosterone treatment [33], and have been reviewed elsewhere [4].
Bonitos with low content of malodorous trimethylamine as palliative care for self-reported Japanese trimethylaminuria subjects
2009, Drug Metabolism and PharmacokineticsStop codon mutations in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population
2007, Molecular Genetics and MetabolismTrimethylaminuria: A perhaps not so uncommon case
2020, Revue Medicale SuisseMicrobiota and malodor—etiology and management
2020, International Journal of Molecular SciencesFirst case of currarino syndrome and trimethylaminuria: Two rare diseases for a complex clinical presentation
2016, Journal of Digestive Diseases
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Current address: Showa Pharmaceutical University, Laboratory of Drug Metabolism and Pharmacokinetics, Tokyo, Japan