Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume 1812, Issue 8, August 2011, Pages 867-878
ReviewRole of nuclear receptors for bile acid metabolism, bile secretion, cholestasis, and gallstone disease☆
Under an Elsevier user license
open archive
Research Highlights
►Nuclear receptors control hepatobiliary transport and phase I/II metabolism of bile acids and drugs. ►Nuclear receptors modulate hepatic inflammation. ►Hereditary and acquired alterations of NR help to understand cholestasis and gallstone disease pathogenesis. ►Nuclear receptors represent attractive drug targets for cholestasis and gallstone disease.
Keywords
Bile acids
Nuclear receptors
FXR
Cholestasis
Gallstone
Bile acid transport
Cited by (0)
- ☆
This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease.
Copyright © 2010 Elsevier B.V. All rights reserved.