Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Volume 1823, Issue 9, September 2012, Pages 1568-1579
ReviewCell biology of molybdenum in plants and humans☆
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Highlights
► Mo needs to be complexed by a special cofactor in order to gain catalytic activity. ► The molybdenum cofactor (Moco) forms the active site of all eukaryotic Mo enzymes. ► Mo enzymes are an essential part of the global carbon, nitrogen and sulfur cycles. ► Moco is synthesized by a conserved pathway that consists of four steps. ► Iron and copper are involved in Mo metabolism in eukaryotes.
Abbreviations
AO
aldehyde oxidase
cPMP
cyclic pyranopterin monophosphate
Cu
copper
Fe
iron
Mo
molybdenum
Moco
molybdenum cofactor
MoBP
molybdenum cofactor binding protein
MPT
molybdopterin
NR
nitrate reductase
SO
sulfite oxidase
XDH
xanthine dehydrogenase
XO
xanthine oxidase
Keywords
Molybdenum cofactor
Molybdenum deficiency
Sulfite oxidase
Nitrate reductase
Xanthine dehydrogenase
Aldehyde oxidase
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This article is part of a Special Issue entitled: Cell Biology of Metals.
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