Antiviral activity of berberine and related compounds against human cytomegalovirus

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Abstract

Berberine chloride (1) and the structurally related compounds were assessed for the anti-human cytomegalovirus (HCMV) activity using the plaque assay. The anti-HCMV activity (IC50 0.68 μM) of 1 was equivalent to that (IC50 0.91 μM) of ganciclovir (GCV). The mechanism of action by which 1 inhibits the replication of HCMV is presumed to be different from that of GCV; 1 would interfere with intracellular events after virus penetration into the host cells and before viral DNA synthesis.

Graphical abstract

Berberine chloride (1) inhibited the human cytomegalovirus replication at IC50 0.68 μM, which was equivalent to that (0.91 μM) for ganciclovir. The selectivity index of 1, the ratio of 50% cytotoxic concentration to IC50, was 110.

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