Short CommunicationPartial deletion of glial cell line-derived neurotrophic factor (GDNF) in mice: Effects on sucrose reward and striatal GDNF concentrations
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Acknowledgments
Grant support: WCG T32 DA07288 and DA14185; LDM P50 DA16511 and DA14185; ACG DAMD99-1-9780 and AG023630.
References (25)
- et al.
Exogenous NGF restores endogenous NGF distribution in the brain of the cognitively impaired aged rat
Brain Res.
(2003) - et al.
Glial cell line-derived neurotrophic factor-conjugated nanoparticles suppress acquisition of cocaine self-administration in rats
Exp. Neurol.
(2005) - et al.
Acquisition of lever pressing for cocaine in C57BL/6 mice: effects of prior Pavlovian conditioning
Pharmacol. Biochem. Behav.
(2003) Drugs of abuse: anatomy, pharmacology and function of reward pathways
Trends Pharmacol. Sci.
(1992)- et al.
Role for GDNF in biochemical and behavioral adaptations to drugs of abuse
Neuron
(2000) - et al.
GDNF and GFRalpha1 promote differentiation and tangential migration of cortical GABAergic neurons
Neuron
(2005) - et al.
Glial cell line-derived neurotrophic factor is essential for neuronal survival in the locus coeruleus-hippocampal noradrenergic pathway
Neuroscience
(2004) - et al.
The neural basis of drug craving: an incentive-sensitization theory of addiction
Brain Res. Brain Res. Rev.
(1993) - et al.
Delayed gene therapy of glial cell line-derived neurotrophic factor is efficacious in a rat model of Parkinson's disease
Brain Res. Mol. Brain Res.
(2005) - et al.
Increased extracellular dopamine concentrations and FosB/DeltaFosB expression in striatal brain areas of heterozygous GDNF knockout mice
Eur. J. Neurosci.
(2004)
Striatal cell type-specific overexpression of DeltaFosB enhances incentive for cocaine
J. Neurosci.
Morphological alterations in the peripheral and central nervous systems of mice lacking glial cell line-derived neurotrophic factor (GDNF): immunohistochemical studies
J. Neurosci.
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2008, Current Opinion in NeurobiologyCitation Excerpt :Indeed, conditional tamoxifen-triggered global removal of GDNF in adult mice leading to the ∼40–60% reduction of striatal GDNF protein levels triggers a profound degeneration of the DA neurons in SNpc, VTA and the most robustly in locus coeruleus within 7 months suggesting that GDNF is absolutely required for the maintenance of the adult DA neuron survival and that GDNF protein levels are critical [17••]. On the other hand, heterozygous GDNF mice with approximately 35–65% decrease in the GDNF protein level show only a slight age-dependent loss of DA neurons [23,24]. Similarly, conditional removal of RET, the bona fide main signalling receptor for GDNF, specifically from the CNS dopamine system during the embryonic development causes a rather mild and late progressive loss of DA neurons starting from about 12 months of age [14••].
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