Original articleClinical endoscopyThe effect of chewing gum on small-bowel transit time in capsule endoscopy: a prospective, randomized trial
Section snippets
Study design, patient population, and randomization
This is a prospective, single-blinded, randomized controlled trial. Between October 2010 and July 2012, consecutive patients who underwent CE at St. Paul's Hospital (Vancouver, British Columbia, Canada) were evaluated for inclusion. Inclusion criteria include 19 years of age and older and outpatient status. Exclusion criteria include previous gastric and/or small-bowel surgery, presence of an ileostomy, dysphagia prohibiting capsule ingestion, diabetes mellitus with evidence of end-organ
Results
A total of 329 patients underwent small-bowel CE between October 2010 and July 2012. Of these patients, 24 did not meet inclusion criteria because of age or inpatient status. Another 146 patients were excluded from the study based on exclusion criteria, and 37 patients declined to participate in the study (Fig. 1). Therefore, 122 patients were enrolled, 60 of whom were randomly assigned to the chewing gum group. A target sample size was reached. All subjects tolerated the procedure well without
Discussion
The capsule camera traverses the gut passively through bowel peristalsis and gravity. Given its limited battery life, a capsule camera only reaches the cecum approximately 83.5% of the time.2 Numerous potential factors for incomplete CE have been identified, including inpatient status, older age, poor bowel preparation, previous small-bowel surgery,37 and diabetes.38 Chewing gum has been proposed to affect bowel motility via 2 mechanisms: the vagal cholinergic stimulation of the bowel and the
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DISCLOSURE: All authors disclosed no financial relationships relevant to this publication.
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