Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population

doi:10.1016/j.neulet.2004.03.066

Neuroscience Letters

Volume 363, Issue 2, 10 June 2004, Pages 139-143

https://doi.org/10.1016/j.neulet.2004.03.066 Get rights and content

Abstract

Alzheimer's disease (AD) is a complex, multifactorial disorder, probably resulting from an interaction between environmental and genetic factors. Increasing evidence points to a link between cholesterol turnover and AD, suggesting that genes implicated in brain cholesterol homeostasis may be potential candidate genes for AD. With this background, we tested the potential association of the CYP46, APOM and APOF genes with the risk of developing AD. CYP46 encodes the enzyme cholesterol 24-hydrolase, which plays a key role in brain cholesterol turnover, and APOF and APOM encode apolipoproteins belonging to the large lipocalin family, which also includes ApoE. In contrast to two previous reports but in accordance with one other, we were unable to detect an association between an intron 2 polymorphism of CYP46 and AD. We also searched for polymorphisms within the APOM and APOF by dHPLC. We were unable to detect any polymorphisms in the coding and exon/intron sequences of the APOF. Finally, we excluded APOM as a genetic determinant of AD in our large French case control population.

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Acknowledgements

We thank Professor David Mann for his helpful discussion.

References (23)

P. Desai et al.
Genetic variation in the cholesterol 24-hydroxylase (CYP46) gene and the risk of Alzheimer's disease
Neurosci. Lett.
(2002)
J.M. Harris et al.
Human leucocyte antigen-A2 increases risk of Alzheimer's disease but does not affect age of onset in a Scottish population
Neurosci. Lett.
(2000)
J. Infante et al.
No synergistic effect between −850 tumor necrosis factor-alpha promoter polymorphism and apolipoprotein E epsilon 4 allele in Alzheimer's disease
Neurosci. Lett.
(2002)
H. Jick et al.
Statins and the risk of dementia
Lancet
(2000)
A. Papassotiropoulos et al.
24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia
J. Psychiatr. Res.
(2002)
X. Wang et al.
Molecular cloning and expression of lipid transfer inhibitor protein reveals its identity with apolipoprotein F
J. Biol. Chem.
(1999)
N. Xu et al.
A novel human apolipoprotein (apoM)
J. Biol. Chem.
(1999)
D. Blacker et al.
Results of a high-resolution genome screen of 437 Alzheimer's disease families
Hum. Mol. Genet.
(2003)
J.S. Collins et al.
Association of a haplotype for tumor necrosis factor in siblings with late-onset Alzheimer disease: the NIMH Alzheimer Disease Genetics Initiative
Am. J. Med. Genet.
(2000)
L.A. Farrer et al.
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium
J. Am. Med. Assoc.
(1997)

K. Fassbender et al.

Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

Proc. Natl. Acad. Sci. USA

(2001)

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Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population

Abstract

Section snippets

Acknowledgements

Neurosci. Lett.

Neurosci. Lett.

Neurosci. Lett.

Lancet

J. Psychiatr. Res.

J. Biol. Chem.

J. Biol. Chem.

Results of a high-resolution genome screen of 437 Alzheimer's disease families

Hum. Mol. Genet.

Association of a haplotype for tumor necrosis factor in siblings with late-onset Alzheimer disease: the NIMH Alzheimer Disease Genetics Initiative

Am. J. Med. Genet.

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

J. Am. Med. Assoc.

Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

Proc. Natl. Acad. Sci. USA