Research ArticlesLymphatic Transport of Halofantrine in the Conscious Rat When Administered as Either the Free Base or the Hydrochloride Salt: Effect of Lipid Class and Lipid Vehicle Dispersion
References and Notes (16)
- et al.
J. Pharm. Sci.
(1996) - et al.
Int. J. Pharm.
(1986) - et al.
J. Pharm. Biomed. Anal.
(1995) - et al.
Int. J. Pharm.
(1985) - et al.
Int. J. Pharm.
(1986) - et al.
Int. J. Pharm.
(1986) - et al.
Br. J. Clin. Pharmacol.
(1989) - et al.
J. Pharm. Pharmacol.
(1986)
Cited by (66)
Intestinal delivery in a long-chain fatty acid formulation enables lymphatic transport and systemic exposure of orlistat
2021, International Journal of PharmaceuticsThe biological fate of orally administered mPEG-PDLLA polymeric micelles
2020, Journal of Controlled ReleaseNano lipid based carriers for lymphatic voyage of anti-cancer drugs: An insight into the in-vitro, ex-vivo, in-situ and in-vivo study models
2020, Journal of Drug Delivery Science and TechnologyConsiderations for Determining Direct Versus Indirect Functional Effects of Solubilizing Excipients on Drug Transporters for Enhancing Bioavailability
2020, Journal of Pharmaceutical SciencesCitation Excerpt :As a result, there has been a significant increase in the number of excipients available as solubility enhancers over the last 2 decades.79-81 Mechanisms for micellar uptake have been implicated in lymphatic delivery, so it is not clear if all the drug absorbed will appear in the systemic circulation.82-86 However, in the absence of well-defined transporter systems for micelles from the lumen or potential membrane interactions across the intestinal barrier, the absorption of free drug is considered the rate-determining factor for bioavailability.
Intestinal lymphatic transport for drug delivery
2011, Advanced Drug Delivery ReviewsCitation Excerpt :Most of the studies have been performed in anesthetized rats, but conscious restrained and unrestrained models have been also described [121]. The unconscious (anesthetized) rat model has been used in various studies [130–135] with various degrees of modification in the site of cannulation, lymph fistulation, feeding and rehydration pre- and post-operative procedures, and dosing [121]. The model is well described elsewhere [131].